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公开(公告)号：US08426455B2
公开(公告)日：2013-04-23
申请号：US12593356
申请日：2008-03-28
IPC分类号： A61K31/42
CPC分类号： C07D263/58 , A61K31/423 , A61K31/47
摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the formula (1), or a salt thereof, and a statin, particularly pitavastatin, in combination.
摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由式（ 1）或其盐，他汀类，特别是匹伐他汀组合。
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公开(公告)号：US20100069433A1
公开(公告)日：2010-03-18
申请号：US12593356
申请日：2008-03-28
CPC分类号： C07D263/58 , A61K31/423 , A61K31/47
摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the following formula (1): , wherein: R1 and R2, which may be identical or different, each represent a hydrogen atom, a methyl group or an ethyl group; R3a, R3b, R4a and R4b, which may be identical or different, each represent a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b are joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or N—R5 (wherein R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, a S(O)l group (l represents a number from 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, and a statin, particularly pitavastatin, in combination.
摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖症或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由下式表示的化合物 （1）表示：其中：R 1和R 2可以相同或不同，各自表示氢原子，甲基或乙基; R3a，R3b，R4a和R4b可以相同或不同，分别表示氢原子，卤素原子，硝基，羟基，C1-4烷基，三氟甲基，C1-4烷氧基 ，C 1-4烷基羰基氧基，二-C 1-4烷基氨基，C 1-4烷基磺酰氧基，C 1-4烷基磺酰基，C 1-4烷基亚磺酰基或C 1-4烷硫基，或R 3a和R 3b ，或R4a和R4b连接以代表亚烷基二氧基; X表示氧原子，硫原子或N-R5（其中，R5表示氢原子，C1-4烷基，C1-4烷基磺酰基或C1-4烷氧基羰基）。 Y表示氧原子，S（O）1基（l表示0〜2的数），羰基，羰基氨基，氨基羰基，磺酰基氨基，氨基磺酰基或NH基。 Z表示CH或N; n表示1〜6的数; m代表2至6的数，或其盐，他汀类，特别是匹伐他汀组合。
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公开(公告)号：US07423009B2
公开(公告)日：2008-09-09
申请号：US10673380
申请日：2003-09-30
申请人： Takashi Nakagawa , Hiroyuki Ishiwata , Toshiaki Takizawa , Toru Kanke , Yasushi Wada , Junichi Kawagoe
发明人： Takashi Nakagawa , Hiroyuki Ishiwata , Toshiaki Takizawa , Toru Kanke , Yasushi Wada , Junichi Kawagoe
CPC分类号： A61K38/4846 , A61K38/08 , A61K38/482 , A61K38/4826 , G01N33/6893 , G01N2500/00 , G01N2800/347
摘要： The present invention relates to a composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of a PAR-2 activating agent which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a composition for prevention and treatment of kidney diseases containing a PAR-2 activating agent which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of a PAR-2 activating agent which is able to activate PAR-2 for the manufacture of a composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.
摘要翻译： 本发明涉及一种用于预防和治疗肾脏疾病的组合物，其包含能够激活PAR-2的PAR-2活化剂的一种或多种有效成分和药学上可接受的载体。 本发明还涉及一种用于预防和治疗肾脏疾病的方法，其包括给予含有能够使患有肾脏疾病的患者PAR-2的PAR-2激活剂的肾脏疾病的预防和治疗组合物，以及 还涉及能够激活PAR-2用于制备用于预防和治疗肾脏疾病的组合物的PAR-2活化剂的用途。 本发明还涉及筛选用于预防和治疗肾脏疾病的有效成分的方法，其包括将测试物质的活化作用筛选到PAR-2。
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公开(公告)号：US06666008B2
公开(公告)日：2003-12-23
申请号：US10177424
申请日：2002-06-21
申请人： Tetsuo Iida , Takao Kobyashi , Kenzo Shimada , Toshiaki Takizawa
发明人： Tetsuo Iida , Takao Kobyashi , Kenzo Shimada , Toshiaki Takizawa
IPC分类号： A01D6900
CPC分类号： A01D69/02 , A01D34/6812 , A01D34/78 , A01D34/828
摘要： An electric lawn mower includes a cutter blade, an electric motor disposed above the cutter blade, and a battery unit for driving the electric motor. The battery unit is positioned above the electric motor to thereby achieve weight balance of the lawn mower. This arrangement allows air to flow smoothly between the electric motor and the battery unit.
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公开(公告)号：USD478042S1
公开(公告)日：2003-08-05
申请号：US29164193
申请日：2002-07-22
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公开(公告)号：US06382297B1
公开(公告)日：2002-05-07
申请号：US09695914
申请日：2000-10-26
IPC分类号： A47H100
CPC分类号： A44B18/0049 , Y10T24/2708 , Y10T24/51
摘要： This invention provides various kinds of engaging devices made of thermoplastic resin material which has an excellent productivity and secures an easiness in handling upon engagement or disengagement and in which breaking of hook element at each end is prevented and the hook element is never pierced into the finger. More specifically, the invention provides an engaging device having a plurality of hook elements disposed in plural rows on a surface of a substrate so as to engage with an engaging portion of a mating member having a plurality of loop elements on a surface thereof. Projections risen substantially vertically from a surface of the substrate are formed integrally therewith so as to secure protection function and backup function.
摘要翻译： 本发明提供了各种由热塑性树脂材料制成的接合装置，其具有优异的生产率并且在接合或脱开时确保操作的容易性，并且其中防止每个端部处的钩元件的断裂并且钩元件不会刺入手指 。 更具体地，本发明提供了一种接合装置，其具有在基板的表面上设置成多列的多个钩元件，以便与其表面上具有多个环形元件的配合构件的接合部分接合。 从基板的表面大致垂直地突出的突起与其一体地形成，从而确保保护功能和备用功能。
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公开(公告)号：US06375647B1
公开(公告)日：2002-04-23
申请号：US09629267
申请日：2000-07-31
IPC分类号： A61M1600
CPC分类号： A61F13/622
摘要： The present invention provides a disposable diaper, which is easy to put on the wearer, and which is possible to be put on easily when the wearer is standing on both legs. The disposable diaper including a diaper body having a hip portion and a belly portion, which are spread out with a crotch portion between them. The disposable diaper includes engaging means, which are arranged to be attachable/detachable, on the both side portions of the hip portion and the belly portion. The engaging means have hook elements which are disposed on the hip portion and projecting toward the belly portion, engaging faces disposed on the hook elements and facing to the hip portion, hook elements which are disposed on the belly portion and projecting toward the hip portion and engaging faces disposed on the hook elements and which are facing to the belly portion. At least one of the hook elements is sandwiched between the hook elements, so that the engaging faces come into contact with each other to engage the hook elements each other.
摘要翻译： 本发明提供一种便于穿戴者使用的一次性尿布，并且当穿戴者站在两条腿上时可以容易地放置。 一次性尿布包括具有臀部和腹部的尿布主体，它们之间具有裆部部分。 一次性尿布包括在臀部和腹部的两侧部分上设置为可附接/拆卸的接合装置。 接合装置具有钩形元件，其设置在臀部上并朝向腹部突出，配置在钩元件上并面向臀部的接合面，设置在腹部上并朝向臀部部突出的钩元件， 布置在钩元件上并且面向腹部的接合面。 钩元件中的至少一个夹在钩元件之间，使得接合面彼此接触以将钩元件彼此接合。
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公开(公告)号：US6143222A
公开(公告)日：2000-11-07
申请号：US701252
申请日：1996-08-21
CPC分类号： B29C47/32 , A44B18/0049 , B29C43/222 , B29C43/28 , B29C43/46 , B29C47/0021 , B29C2043/461 , B29C47/003 , B29C47/0033 , B29L2031/729 , Y10T24/27
摘要： Molten resin is continuously extruded from an extrusion nozzle having a selected width, and at the same time, a plurality of parallel fiber filaments are introduced straightly toward the molten resin outlet in a direction along rotation of a die wheel and/or traversing one or more filaments by a predetermined width. The molten resin extruded from the extrusion nozzle and the filaments are introduced into a predetermined gap for molding a plate-like substrate sheet between the nozzle and the die wheel, which has a multiplicity of hook-forming cavities in its circumferential surface and is rotatable in one direction, and at the same time, the hook-forming cavities are filled with a part of the molten resin. The filaments are embedded in the substrate sheet of the extruded molten resin as the die wheel is driven to rotate in the direction of extrusion of the molten resin, and a plurality of hooks are continuously molded on a surface of the substrate sheet.
摘要翻译： 熔融树脂从具有选定宽度的挤出喷嘴连续挤出，并且同时多个平行的纤维细丝在沿着模轮转动的方向上直接引向熔融树脂出口和/或穿过一个或多个 长丝以预定的宽度。 从挤出喷嘴和长丝挤出的熔融树脂被引入到预定的间隙中，用于在喷嘴和模轮之间成型板状基材片，其在其圆周表面上具有多个钩形成腔，并且可旋转 一个方向，并且同时，钩形成腔被一部分熔融树脂填充。 当模轮被驱动以在熔融树脂的挤出方向上旋转时，将长丝嵌入挤出的熔融树脂的基片中，并且在基片的表面上连续地模制多个钩。
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公开(公告)号：US5800760A
公开(公告)日：1998-09-01
申请号：US714306
申请日：1996-09-18
CPC分类号： A44B18/0049 , B29C43/222 , B29C43/46 , B29C47/0021 , B29C47/003 , B29C47/0033 , B29C47/705 , B29C2043/461 , B29L2031/729
摘要： A fastening connector of thermoplastic resin for connecting two separate members together is continuously molded efficiently in a single step by a simple method and apparatus. The method includes the steps of continuously extruding molten resin from an injection nozzle to the circumferential surface of a die wheel, which has in the circumferential surface, a multiplicity of engaging-element-forming cavities, to continuously mold a substrate sheet between the circumferential surface of the die wheel and the injection nozzle and a multiplicity of engaging elements in the engaging-element-forming cavities which elements stand on a front surface of the substrate sheet and, at the same time, to continuously mold at least one engaging ridge, through an engaging-ridge-molding channel, with part of the molten resin integrally with a rear surface of the substrate sheet.
摘要翻译： 用于将两个分开的部件连接在一起的热塑性树脂的紧固连接器通过简单的方法和装置在一个步骤中被有效地连续模制。 该方法包括以下步骤：将熔融树脂从注射喷嘴连续挤出到在圆周表面上具有多个接合元件形成腔的模轮的圆周表面，以将基片在圆周表面 模具轮和注射喷嘴之间的多个接合元件以及位于接合元件形成腔中的多个接合元件，该元件位于基片的前表面上，并且同时连续地模制至少一个接合脊，通过 一个接合脊模制通道，其中一部分熔融树脂与基片的后表面一体化。
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公开(公告)号：US5544387A
公开(公告)日：1996-08-13
申请号：US228261
申请日：1994-04-15
申请人： Toru Yamamoto , Akihiko Hisano , Toshiaki Takizawa
发明人： Toru Yamamoto , Akihiko Hisano , Toshiaki Takizawa
CPC分类号： A47H13/00 , A47H13/14 , Y10T16/353 , Y10T16/354 , Y10T16/375 , Y10T24/2708 , Y10T24/45288 , Y10T24/49 , Y10T24/51
摘要： A molded curtain attachment connector for connecting a curtain hanger member and the top edge of a curtain includes a fastener member having a fastener surface releasably engageable with the fastener surface of a surface-type separable fastener member attached to the curtain along a top edge thereof, a hook member integrally formed with the fastener member and adapted to be attached to, and detached from, the curtain hanger member, and a blocking means disposed at the opening of the hook member for preventing another article from entering the hook member through the opening, the blocking means being deformable toward the inside of the hook member when subjected to an external force of a predetermined intensity. The molded curtain attachment connector thus constructed can be manufactured with high production efficiency, facilitates the curtain attaching/detaching operation, ensures smooth opening and closing operation of the curtain, and can be colored in various manners.
摘要翻译： 用于连接帘式衣架构件和帘幕顶部边缘的模制窗帘连接连接器包括紧固件构件，该紧固件具有可沿着其顶部边缘可附接到窗帘的表面型可分离紧固件的紧固件表面可释放地接合的紧固件表面， 与所述紧固件一体地形成并适于附接到所述帘挂架构件和从所述帘挂架构件分离的钩构件，以及设置在所述钩构件的开口处的阻挡装置，用于防止另一物品通过所述开口进入所述钩构件， 当经受预定强度的外力时，阻挡装置可朝向钩构件的内部变形。 这样构成的模制窗帘安装连接器可以以高生产效率制造，便于幕面安装/拆卸操作，确保帘幕的平稳的打开和关闭操作，并且可以以各种方式着色。
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