发明申请
- 专利标题： MUTANT POLYPEPTIDE HAVING EFFECTOR FUNCTION
- 专利标题（中）： 具有影响功能的突变多肽
-
申请号： US12296901申请日： 2007-04-12
-
公开(公告)号： US20100080794A1公开(公告)日： 2010-04-01
- 发明人: Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
- 申请人： Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
- 优先权： JP2006-111957 20060414; JP2006-119607 20060424
- 国际申请： PCT/JP2007/058103 WO 20070412
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; C07H21/04 ; C12N15/63 ; C12N5/10 ; C12P21/00
摘要：
Mutant polypeptides of the present invention contain an Fc region in which a cysteine residue is substituted for the second amino acid from the glycosylation site to the N terminal side in the Fc region. The Fc region is preferably a human IgG Fc region. The mutant polypeptides of the present invention may also contain an N-linked sugar chain at the glycosylation site in Fc region. Furthermore, a polypeptide domain other than the Fc region of the mutant polypeptides of the present invention may be a polypeptide molecule that recognizes a human cell surface molecule.
信息查询
