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1.发明授权Low-molecular polysulfated hyaluronic acid derivative and medicine containing same 有权低分子多硫酸化透明质酸衍生物及其含有药物公开(公告)号：US08993536B2
公开(公告)日：2015-03-31
申请号：US13143129
申请日：2010-02-01
申请人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
发明人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
IPC分类号： A61K31/728 , A61P11/06 , A61P17/00 , A61P37/08 , C08B37/08
CPC分类号： A61K31/728 , C08B37/0072
摘要： A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SO3H group etc.
摘要翻译： 用于治疗过敏性疾病的低分子量多硫酸化透明质酸衍生物。 用于治疗选自以下通式（IA）或（IB）表示的花粉病，过敏性鼻炎，过敏性结膜炎，特应性皮炎和哮喘的过敏性疾病的药剂; 其中n表示0〜15的数; R各自独立地表示氢原子或SO 3 H基等
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公开(公告)号：US20120047586A9
公开(公告)日：2012-02-23
申请号：US12739480
申请日：2008-10-23
申请人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
发明人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
CPC分类号： C07K16/00 , A61K38/00 , C07K16/2887 , C07K2317/72 , C07K2317/732 , C07K2319/30 , C07K2319/33
摘要： Disclosed is a polypeptide having an enhanced effector function. Specifically disclosed are: a polypeptide having a modified Fc region; a nucleic acid encoding the polypeptide; a vector carrying the nucleic acid; a host cell or a host organism harboring the vector; a pharmaceutical composition comprising the polypeptide; a method for producing the polypeptide; a method for enhancing the effector function of an antibody; and a method for producing a cell capable of producing an antibody having a high effector function.
摘要翻译： 公开了具有增强的效应子功能的多肽。 具体公开的是：具有修饰的Fc区的多肽; 编码该多肽的核酸; 携带核酸的载体; 携带载体的宿主细胞或宿主生物体; 包含该多肽的药物组合物; 一种生产该多肽的方法; 用于增强抗体的效应子功能的方法; 以及能够产生具有高效应功能的抗体的细胞的制备方法。
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公开(公告)号：US07716733B2
公开(公告)日：2010-05-11
申请号：US11563058
申请日：2006-11-24
CPC分类号： G06F21/31 , G06F3/0482 , G06F21/6263
摘要： The information terminal device of the invention has a first function of displaying non-confidential data in a selectable manner on its display screen and, in response to the user's selection of the non-confidential data, showing the details of the non-confidential data. The information terminal device also has a second function of displaying confidential data in a selectable manner and, in response to the user's selection of the confidential data, showing the details of the confidential data. The first function is given as one normally selectable menu option and is activated by the user's selection of the corresponding menu. The second function is, however, not given as a normally selectable menu option and is triggered only by the user's series of operations of an operation unit in a preset sequence. No operation-related display appears on the display screen of the information terminal device during the user's series of operations of the operation unit. The information terminal device of this configuration does not hint even the presence of confidential data to any third person and thus effectively prevents the third person from analyzing or decoding the data stored in the information terminal device and having illegal access to the confidential data. This arrangement of the invention desirably enables the safe handling of confidential data without the potential for leakage of the confidential data from the information terminal device.
摘要翻译： 本发明的信息终端装置具有以可选择的方式在其显示屏上显示非机密数据的第一功能，并且响应于用户对非机密数据的选择，显示非机密数据的细节。 信息终端装置还具有以可选择的方式显示机密数据的第二功能，并且响应于用户对秘密数据的选择，显示机密数据的细节。 第一个功能是一个通常可选择的菜单选项，由用户选择相应的菜单激活。 然而，第二功能没有被给予作为通常可选择的菜单选项，并且仅由用户在预设序列中的操作单元的一系列操作来触发。 在操作单元的用户一系列操作期间，信息终端设备的显示屏上不显示与操作有关的显示。 该配置的信息终端装置也不向任何第三人员提供机密数据的存在，从而有效地防止第三人员分析或解码存储在信息终端装置中的数据，并且非法访问机密数据。 本发明的这种安排希望能够安全地处理机密数据，而不会使机密数据从信息终端设备泄漏。
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公开(公告)号：US20100080794A1
公开(公告)日：2010-04-01
申请号：US12296901
申请日：2007-04-12
申请人： Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
发明人： Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
CPC分类号： C07K14/47 , C07K16/2887 , C07K2317/41 , C07K2317/72 , C07K2317/732
摘要： Mutant polypeptides of the present invention contain an Fc region in which a cysteine residue is substituted for the second amino acid from the glycosylation site to the N terminal side in the Fc region. The Fc region is preferably a human IgG Fc region. The mutant polypeptides of the present invention may also contain an N-linked sugar chain at the glycosylation site in Fc region. Furthermore, a polypeptide domain other than the Fc region of the mutant polypeptides of the present invention may be a polypeptide molecule that recognizes a human cell surface molecule.
摘要翻译： 本发明的突变体多肽含有Fc区，其中半胱氨酸残基取代Fc区中糖基化位点至N末端侧的第二个氨基酸。 Fc区优选为人IgG Fc区。 本发明的突变体多肽还可以在Fc区的糖基化位点含有N-连接的糖链。 此外，本发明的突变多肽的Fc区以外的多肽结构域可以是识别人细胞表面分子的多肽分子。
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公开(公告)号：US08765669B2
公开(公告)日：2014-07-01
申请号：US12999654
申请日：2009-06-15
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
CPC分类号： C07K14/605 , A61K38/00
摘要： Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers.
摘要翻译： 添加糖链的GLP-1肽在血液中更稳定，并且在没有添加低聚糖的情况下比GLP-1肽更有效地控制血糖水平。 具有GLP-1活性的添加糖链的GLP-1肽包括GLP-1中由糖链连接的氨基酸取代的至少一个或至少两个氨基酸; 具有GLP-1的氨基酸序列的肽，其具有缺失，取代或添加一个或几个氨基酸; 或GLP-1类似物。 具有至少一个被寡糖链添加的氨基酸取代的氨基酸的添加糖链的GLP-1肽包括具有寡聚透明质酸的寡糖链。 寡糖链添加的氨基酸包括通过接头连接到氨基酸的寡糖链。
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公开(公告)号：US08507429B2
公开(公告)日：2013-08-13
申请号：US13152082
申请日：2011-06-02
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.
摘要翻译： 本发明涉及一种与GLP-1相比血液中稳定性更高的糖链附加GLP-1肽，优选表现出比GLP-1更高的控制血糖水平的活性。 本发明涉及：（a）GLP-1;具有GLP-1活性的附加了糖链的GLP-1肽，其中至少一个氨基酸被添加了糖链的氨基酸取代。 （b）具有缺失，取代或添加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或（c）GLP-1类似物。
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公开(公告)号：US20110245166A1
公开(公告)日：2011-10-06
申请号：US13152082
申请日：2011-06-02
申请人： Yasuhiro KAJIHARA , Takashi TSUJI , Izumi SAKAMOTO , Yuri NAMBU , Kazuhiro FUKAE , Katsunari TEZUKA , Hiroaki ASAI
发明人： Yasuhiro KAJIHARA , Takashi TSUJI , Izumi SAKAMOTO , Yuri NAMBU , Kazuhiro FUKAE , Katsunari TEZUKA , Hiroaki ASAI
IPC分类号： A61K38/26 , C07K14/605 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.
摘要翻译： 本发明涉及一种与GLP-1相比血液中稳定性更高的糖链附加GLP-1肽，优选表现出比GLP-1更高的控制血糖水平的活性。 本发明涉及：（a）GLP-1;具有GLP-1活性的附加了糖链的GLP-1肽，其中至少一个氨基酸被添加了糖链的氨基酸取代。 （b）具有缺失，取代或添加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或（c）GLP-1类似物。
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8.发明申请METHOD FOR RESTORING MISSING TOOTH AND METHOD FOR PRODUCING RESTORATIVE MATERIAL 审中-公开恢复缺牙的方法和生产复原材料的方法公开(公告)号：US20110212414A1
公开(公告)日：2011-09-01
申请号：US13059847
申请日：2009-08-19
申请人： Takashi Tsuji , Etsuko Ikeda , Hiroaki Asai
发明人： Takashi Tsuji , Etsuko Ikeda , Hiroaki Asai
CPC分类号： A61L27/3834 , A61L27/3813 , A61L27/3865 , A61L27/3891
摘要： A method of producing a restorative material used to restore a tooth-deficient area in an oral cavity, the method comprising: positioning, in a support carrier, a first cell mass formed from either mesenchymal cells or epithelial cells and a second cell mass formed from the other of the mesenchymal cells or epithelial cells, one of the mesenchymal cells or epithelial cells being derived from a tooth germ and the first and second cell masses being not mixed with each other but made to closely contact each other; culturing the first and second cell masses to form a reconstructed tooth germ or tooth; and confirming directionality of the reconstructed tooth germ or tooth formed by the culturing so as to enable the reconstructed tooth germ or tooth to be embedded in the tooth-deficient area such that a tip of the tooth faces an interior of the oral cavity, the tooth germ or tooth whose directionality has been confirmed being used as a restorative material to obtain an equivalent of a missing tooth in the tooth-deficient area. A method for restoring a tooth-deficient area, the method comprising; embedding the reconstructed tooth germ or tooth obtained by the production method in the tooth-deficient area.
摘要翻译： 一种生产用于恢复口腔缺牙区域的修复材料的方法，所述方法包括：在载体载体中定位由间充质细胞或上皮细胞形成的第一细胞块和由 间质细胞或上皮细胞中的另一个，间充质细胞或上皮细胞之一来自牙胚，第一和第二细胞团彼此不混合但彼此紧密接触; 培养第一和第二细胞块以形成重建的牙胚或牙齿; 并且确定通过培养形成的重建牙胚或牙齿的方向性，以使重建的牙胚或牙齿能够嵌入牙齿缺损区域，使得牙齿的尖端面向口腔内部，牙齿 确定其方向性的胚芽或牙齿用作修复材料以获得缺牙区域中缺失牙齿的当量。 一种用于恢复牙缺陷区域的方法，所述方法包括： 将通过生产方法获得的重建牙胚或牙齿嵌入牙缺陷区域。
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公开(公告)号：US07985731B2
公开(公告)日：2011-07-26
申请号：US12140866
申请日：2008-06-17
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.
摘要翻译： 本发明涉及一种与GLP-1相比血液中稳定性更高的糖链附加GLP-1肽，优选表现出比GLP-1更高的控制血糖水平的活性。 本发明涉及：（a）GLP-1;具有GLP-1活性的附加了糖链的GLP-1肽，其中至少一个氨基酸被添加了糖链的氨基酸取代。 （b）具有缺失，取代或添加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或（c）GLP-1类似物。
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公开(公告)号：US20090111739A1
公开(公告)日：2009-04-30
申请号：US12140866
申请日：2008-06-17
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.
摘要翻译： 本发明涉及一种与GLP-1相比血液中稳定性更高的糖链附加GLP-1肽，优选表现出比GLP-1更高的控制血糖水平的活性。 本发明涉及：（a）GLP-1;具有GLP-1活性的附加了糖链的GLP-1肽，其中至少一个氨基酸被添加了糖链的氨基酸取代。 （b）具有缺失，取代或添加一个或几个氨基酸的具有GLP-1氨基酸序列的肽; 或（c）GLP-1类似物。
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