发明申请
- 专利标题： Transporters Comprising Spaced Arginine Moieties
- 专利标题（中）： 包含间隔精氨酸部分的运输商
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申请号： US12553649申请日： 2009-09-03
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公开(公告)号： US20100081618A1公开(公告)日： 2010-04-01
- 发明人: Paul A. Wender , Jonathan B. Rothbard , Lee Wright , Erik L. Kreider , Christopher L. VanDeusen
- 申请人： Paul A. Wender , Jonathan B. Rothbard , Lee Wright , Erik L. Kreider , Christopher L. VanDeusen
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/10 ; A61K38/08 ; A61P43/00
摘要：
The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.
公开/授权文献
- US2585310A Lunch box 公开/授权日：1952-02-12
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