利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.025 秒)

    Transporters comprising spaced arginine moieties
    1.
    发明授权
    Transporters comprising spaced arginine moieties 失效
    包含间隔精氨酸部分的转运蛋白

    公开(公告)号：US07585834B2

    公开(公告)日：2009-09-08

    申请号：US10078247

    申请日：2002-02-14

    申请人： Paul A. Wender ,  Jonathan B. Rothbard ,  Lee Wright ,  Erik L. Kreider ,  Christopher L. VanDeusen

    发明人： Paul A. Wender ,  Jonathan B. Rothbard ,  Lee Wright ,  Erik L. Kreider ,  Christopher L. VanDeusen

    IPC分类号： A61K38/00 ,  C12P13/10

    CPC分类号： A61K47/64

    摘要： The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.

    摘要翻译： 本发明提供用于增强生物活性化合物跨越生物膜并跨越动物上皮细胞或内皮组织的转运的组合物和方法。 组合物包括生物活性剂和运输部分。 运输部分包括选自（ZYZ）nZ，（ZY）nZ，（ZYY）nZ和（ZYYY）nZ的结构。 亚基“Z”是L-精氨酸或D-精氨酸，亚基“Y”是不包含脒基或胍基部分的氨基酸。 下标“n”是从2到10的整数。用于增强转运的方法涉及上述组合物的给药。

    Transporters Comprising Spaced Arginine Moieties
    2.
    发明申请
    Transporters Comprising Spaced Arginine Moieties 审中-公开
    包含间隔精氨酸部分的运输商

    公开(公告)号：US20100081618A1

    公开(公告)日：2010-04-01

    申请号：US12553649

    申请日：2009-09-03

    申请人： Paul A. Wender ,  Jonathan B. Rothbard ,  Lee Wright ,  Erik L. Kreider ,  Christopher L. VanDeusen

    发明人： Paul A. Wender ,  Jonathan B. Rothbard ,  Lee Wright ,  Erik L. Kreider ,  Christopher L. VanDeusen

    IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  A61P43/00

    CPC分类号： A61K47/64

    摘要： The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.

    摘要翻译： 本发明提供用于增强生物活性化合物跨越生物膜并跨越动物上皮细胞或内皮组织的转运的组合物和方法。 组合物包括生物活性剂和运输部分。 运输部分包括选自（ZYZ）nZ，（ZY）nZ，（ZYY）nZ和（ZYYY）nZ的结构。 亚基“Z”是L-精氨酸或D-精氨酸，亚基“Y”是不包含脒基或胍基部分的氨基酸。 下标“n”是从2到10的整数。用于增强转运的方法涉及上述组合物的给药。

    Transporters Comprising Spaced Arginine Moieties
    3.
    发明申请
    Transporters Comprising Spaced Arginine Moieties 审中-公开
    包含间隔精氨酸部分的运输商

    公开(公告)号：US20120225826A1

    公开(公告)日：2012-09-06

    申请号：US13248783

    申请日：2011-09-29

    申请人： Paul A. Wender ,  Jonathan B. Rothbard ,  Lee Wright ,  Erik L. Kreider ,  Christopher J. VanDeusen

    发明人： Paul A. Wender ,  Jonathan B. Rothbard ,  Lee Wright ,  Erik L. Kreider ,  Christopher J. VanDeusen

    IPC分类号： A61K38/08 ,  A61K38/16 ,  A61K38/13 ,  A61K38/10

    CPC分类号： A61K47/64

    摘要： The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.

    摘要翻译： 本发明提供用于增强生物活性化合物跨越生物膜并跨越动物上皮细胞或内皮组织的转运的组合物和方法。 组合物包括生物活性剂和运输部分。 运输部分包括选自（ZYZ）nZ，（ZY）nZ，（ZYY）nZ和（ZYYY）nZ的结构。 亚基“Z”是L-精氨酸或D-精氨酸，亚基“Y”是不包含脒基或胍基部分的氨基酸。 下标“n”是从2到10的整数。用于增强转运的方法涉及上述组合物的给药。

    BLADE PROTECTOR AND GRIP
    5.
    发明申请
    BLADE PROTECTOR AND GRIP 审中-公开

    公开(公告)号：US20170368432A1

    公开(公告)日：2017-12-28

    申请号：US15698933

    申请日：2017-09-08

    申请人： Lee Wright

    发明人： Lee Wright

    IPC分类号： A63B60/14 ,  A63B59/70 ,  A63B60/50 ,  B25G1/10

    CPC分类号： A63B60/14 ,  A63B59/70 ,  A63B60/08 ,  A63B60/50 ,  A63B2209/00 ,  B25G1/102

    摘要： Disclosed is apparatus for use with a sports stick of the type that has a portion which, in use, is typically covered with a grippable material. The apparatus includes a body of heat shrink material, the body being adapted to receive the portion in spaced-relation and further adapted, upon receipt of heat and when in receipt of the portion, to shrink to a working size that surrounds the portion in close-fitting relation. The body can be provided with features that, at least when the body is shrunk to the working size, renders the body grippable. The features can be apertures.