发明申请
US20100092384A1 MULTIFUNCTIONAL NANOPARTICLES AND COMPOSITIONS AND METHODS OF USE THEREOF
审中-公开
多功能纳米颗粒及其组合物及其使用方法
- 专利标题： MULTIFUNCTIONAL NANOPARTICLES AND COMPOSITIONS AND METHODS OF USE THEREOF
- 专利标题（中）： 多功能纳米颗粒及其组合物及其使用方法
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申请号： US12531841申请日： 2008-03-17
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公开(公告)号： US20100092384A1公开(公告)日： 2010-04-15
- 发明人: Ambika Bumb , Martin W. Brechbiel , Peter Choyke , Lars Fugger , Peter James Dobson
- 申请人： Ambika Bumb , Martin W. Brechbiel , Peter Choyke , Lars Fugger , Peter James Dobson
- 申请人地址： US MD BETHESDA GB Oxfordshire
- 专利权人： The jUnited States of America as represented by Secretary, Dept. of Health and Human Service,University of Oxford
- 当前专利权人： The jUnited States of America as represented by Secretary, Dept. of Health and Human Service,University of Oxford
- 当前专利权人地址： US MD BETHESDA GB Oxfordshire
- 国际申请： PCT/US08/57206 WO 20080317
- 主分类号： A61K49/06
- IPC分类号： A61K49/06 ; A61K49/18 ; A61K49/00
摘要：
Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment.
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