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1.发明申请公开(公告)号：US20100092384A1
公开(公告)日：2010-04-15
申请号：US12531841
申请日：2008-03-17
CPC分类号： G01N33/54346 , A61K49/183 , A61K49/1875 , B82Y5/00
摘要： Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment.
摘要翻译： 本发明提供一种多功能颗粒，其包括：（a）内金属芯，（b）生物相容性壳，其包含嵌入其中的光学造影剂，和（c）通过多齿配体与生物相容性壳结合的靶向生物分子，其中所述多齿配体 与成像剂螯合。 还提供了包含多功能颗粒的组合物和使用多功能颗粒的方法，包括诊断成像的方法和治疗方法。
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公开(公告)号：US09358306B2
公开(公告)日：2016-06-07
申请号：US14126060
申请日：2012-06-27
IPC分类号： A61K39/00 , A61K49/16 , A61K47/48 , A61K41/00 , C07K16/28 , C07K16/30 , C07K16/32 , A61K31/704 , A61K39/395 , A61K45/06 , C07K16/40 , G01N33/50 , A44C15/00 , A41D13/00
CPC分类号： A61K47/48646 , A41D13/0002 , A41D2400/32 , A44C15/00 , A61K31/704 , A61K41/0071 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K2039/505 , C07K16/2863 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/73 , C07K2317/77 , G01N33/5011 , A61K2300/00
摘要： The present disclosure relates to compositions and methods of killing cells. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein, such as a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm−2. The cell is also contacted with one or more therapeutic agents (such as an anti-cancer agent), for example about 0 to 8 hours after irradiating the cell, thereby killing the cell. Also provided are methods of imaging cell killing in real time, using fluorescence lifetime imaging. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.
摘要翻译： 本公开涉及杀死细胞的组合物和方法。 在具体实例中，该方法包括使具有细胞表面蛋白的细胞与治疗有效量的抗体-IR700分子接触，其中该抗体特异性结合细胞表面蛋白，例如表面上的肿瘤特异性抗原 肿瘤细胞。 随后以至少1J cm -2的剂量照射细胞，例如在660至740nm的波长处。 细胞还与一种或多种治疗剂（例如抗癌剂）接触，例如在照射细胞后约0至8小时，从而杀死细胞。 还提供了使用荧光寿命成像实时成像细胞杀伤的方法。 还提供了可穿戴装置，其包括衣物，饰品或覆盖物; 以及纳入该制品中的NIR LED，其可以与所公开的方法一起使用。
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公开(公告)号：US20140120119A1
公开(公告)日：2014-05-01
申请号：US14126060
申请日：2012-06-27
IPC分类号： A61K41/00
CPC分类号： A61K47/48646 , A41D13/0002 , A41D2400/32 , A44C15/00 , A61K31/704 , A61K41/0071 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K2039/505 , C07K16/2863 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/73 , C07K2317/77 , G01N33/5011 , A61K2300/00
摘要： The present disclosure relates to compositions and methods of killing cells. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein, such as a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm−2. The cell is also contacted with one or more therapeutic agents (such as an anti-cancer agent), for example about 0 to 8 hours after irradiating the cell, thereby killing the cell. Also provided are methods of imaging cell killing in real time, using fluorescence lifetime imaging. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.
摘要翻译： 本公开涉及杀死细胞的组合物和方法。 在具体实例中，该方法包括使具有细胞表面蛋白的细胞与治疗有效量的抗体-IR700分子接触，其中该抗体特异性结合细胞表面蛋白，例如表面上的肿瘤特异性抗原 肿瘤细胞。 随后以至少1J cm -2的剂量照射细胞，例如在660至740nm的波长处。 细胞还与一种或多种治疗剂（例如抗癌剂）接触，例如在照射细胞后约0至8小时，从而杀死细胞。 还提供了使用荧光寿命成像实时成像细胞杀伤的方法。 还提供了可穿戴装置，其包括衣物，饰品或覆盖物; 以及纳入该制品中的NIR LED，其可以与所公开的方法一起使用。
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4.发明申请Methods for imaging the lymphatic system using dendrimer-based contrast agents 审中-公开使用基于树枝状大分子的造影剂对淋巴系统成像的方法公开(公告)号：US20050171424A1
公开(公告)日：2005-08-04
申请号：US10756948
申请日：2004-01-13
CPC分类号： A61K49/124 , A61K49/0002 , A61K49/189 , B82Y5/00
摘要： Methods are disclosed for lymphatic system imaging using dendrimer conjugates as contrast agents. The disclosed methods are applicable to the imaging of all lymphatic structures, but in particular embodiments are particularly suited for imaging specific parts of the lymphatic system such as lymph nodes or lymphatic vessels. The methods permit the assessment of abnormal conditions within the lymphatic system, such as lymphoma/lymphoproliferative disease, inflammation, and cancer metastasis. The methods also may be used to identify and locate lymph nodes into which lymph fluid flows from a tumor.
摘要翻译： 公开了使用树枝状大分子缀合物作为造影剂的淋巴系统成像的方法。 所公开的方法适用于所有淋巴结构的成像，但是在具体实施方案中特别适合于成像诸如淋巴结或淋巴管的淋巴系统的特定部分。 该方法允许评估淋巴系统内的异常状况，例如淋巴瘤/淋巴增生性疾病，炎症和癌症转移。 这些方法还可用于鉴定和定位淋巴结从淋巴液流向其中的淋巴结。
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公开(公告)号：US20120010558A1
公开(公告)日：2012-01-12
申请号：US13180111
申请日：2011-07-11
CPC分类号： C07K16/30 , A41D13/0002 , A41D2400/32 , A44C15/00 , A61K41/0071 , A61K47/6803 , A61K47/6869 , A61K49/0032 , A61K49/0058 , A61K2039/505 , C07K16/2863 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/73
摘要： The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm−2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.
摘要翻译： 本公开涉及在体外或体内杀死细胞的组合物和方法。 在具体实例中，该方法包括使具有细胞表面蛋白的细胞与治疗有效量的抗体-IR700分子接触，其中抗体特异性结合细胞表面蛋白。 在具体实例中，抗体识别肿瘤细胞表面上的肿瘤特异性抗原。 随后以至少1J cm -2的剂量照射细胞，例如在660至740nm的波长处，从而杀死细胞。 还提供了可穿戴装置，其包括衣物，饰品或覆盖物; 以及纳入该制品中的NIR LED，其可以与所公开的方法一起使用。
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公开(公告)号：US08524239B2
公开(公告)日：2013-09-03
申请号：US13180111
申请日：2011-07-11
CPC分类号： C07K16/30 , A41D13/0002 , A41D2400/32 , A44C15/00 , A61K41/0071 , A61K47/6803 , A61K47/6869 , A61K49/0032 , A61K49/0058 , A61K2039/505 , C07K16/2863 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/73
摘要： The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm−2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.
摘要翻译： 本公开涉及在体外或体内杀死细胞的组合物和方法。 在具体实例中，该方法包括使具有细胞表面蛋白的细胞与治疗有效量的抗体-IR700分子接触，其中抗体特异性结合细胞表面蛋白。 在具体实例中，抗体识别肿瘤细胞表面上的肿瘤特异性抗原。 随后以至少1J cm -2的剂量照射细胞，例如在660至740nm的波长处，从而杀死细胞。 还提供了可穿戴装置，其包括衣物，饰品或覆盖物; 以及纳入该制品中的NIR LED，其可以与所公开的方法一起使用。
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公开(公告)号：US20060204443A1
公开(公告)日：2006-09-14
申请号：US11371780
申请日：2006-03-09
申请人： Hisataka Kobayashi , Peter Choyke
发明人： Hisataka Kobayashi , Peter Choyke
IPC分类号： A61K49/10 , A61N5/00 , A61K31/765
CPC分类号： A61K49/124 , A61K41/009 , A61K47/59 , A61K47/595 , A61N2005/109 , A61N2005/1098
摘要： Methods are disclosed for treating a tumor. A dendrimer conjugate is administered to a subject having a tumor. The dendrimer of the dendrimer conjugate is a generation 5 DAB, generation 2 polylysine, or generation 6-8 PAMAM dendrimer. The dendrimer conjugate comprises an effective amount of an anti-tumor agent. The anti-tumor agent is selectively concentrated in the lymphatic system to treat metastatic disease. In certain examples, the anti-tumor agent is an activatable anti-tumor agent and is activated once the anti-tumor agent is selectively concentrated in the lymphatic system.
摘要翻译： 公开了治疗肿瘤的方法。 向具有肿瘤的受试者施用树状聚合物缀合物。 树枝状聚合物缀合物的树枝状大分子是第5代DAB，第2代聚赖氨酸或第6-8个PAMAM树枝状聚合物。 树枝状大分子缀合物包含有效量的抗肿瘤剂。 抗肿瘤剂选择性浓缩在淋巴系统中以治疗转移性疾病。 在某些实例中，抗肿瘤剂是可激活的抗肿瘤剂，一旦抗肿瘤剂选择性地浓缩在淋巴系统中，就被激活。
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