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1.发明申请Method for determining predisposition to manifestation of immune system related diseases 审中-公开确定免疫系统相关疾病表现倾向的方法公开(公告)号：US20060275764A1
公开(公告)日：2006-12-07
申请号：US10537507
申请日：2003-12-02
CPC分类号： C07K16/18 , A61K38/00 , C07K16/40 , C12N9/6424 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to methods for determining predisposition to a manifestation of immune system related diseases, in particular infections, associated with a mutation in the human MASP-2 gene. The invention also features oligonucleotides, polypeptides, peptide fragments and antibodies which are used in the above methods as well as for the manufacture of a medicament for treatment of a disease associated with pathological activity of the lectin-complement pathway. Moreover, the invention provides a series of gene therapy vectors and a kit for diagnosis of the disease associated with a mutation in the human MASP-2 gene.
摘要翻译： 本发明涉及用于确定与人MASP-2基因突变相关的免疫系统相关疾病，特别是感染的表现倾向的方法。 本发明还具有用于上述方法中的寡核苷酸，多肽，肽片段和抗体以及用于制备用于治疗与凝集素补体途径的病理活性相关的疾病的药物。 此外，本发明提供了一系列基因治疗载体和用于诊断与人MASP-2基因突变相关的疾病的试剂盒。
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2.发明申请公开(公告)号：US20100092384A1
公开(公告)日：2010-04-15
申请号：US12531841
申请日：2008-03-17
CPC分类号： G01N33/54346 , A61K49/183 , A61K49/1875 , B82Y5/00
摘要： Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment.
摘要翻译： 本发明提供一种多功能颗粒，其包括：（a）内金属芯，（b）生物相容性壳，其包含嵌入其中的光学造影剂，和（c）通过多齿配体与生物相容性壳结合的靶向生物分子，其中所述多齿配体 与成像剂螯合。 还提供了包含多功能颗粒的组合物和使用多功能颗粒的方法，包括诊断成像的方法和治疗方法。
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公开(公告)号：US08618113B2
公开(公告)日：2013-12-31
申请号：US12373668
申请日：2007-07-16
申请人： Lars Fugger , Manuel Friese
发明人： Lars Fugger , Manuel Friese
IPC分类号： A61K31/505
CPC分类号： A61K31/4965 , A61K38/17
摘要： The invention relates to a method of treatment or prophylaxis of demyelinating disease, in particular the neurodegenerative phase of demyelinating disease, which comprises administration of an acid sensing ion channel (ASIC) antagonist. The invention also relates to a pharmaceutical composition comprising an ASIC antagonist in combination with an additional therapeutic agent, in particular an anti-inflammatory or immunmodulatory agent.
摘要翻译： 本发明涉及治疗或预防脱髓鞘疾病，特别是脱髓鞘疾病的神经变性期的方法，其包括施用酸感应离子通道（ASIC）拮抗剂。 本发明还涉及包含与另外的治疗剂，特别是抗炎或免疫调节剂组合的ASIC拮抗剂的药物组合物。
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公开(公告)号：US20100015127A1
公开(公告)日：2010-01-21
申请号：US12373668
申请日：2007-07-16
申请人： Lars Fugger , Manuel Friese
发明人： Lars Fugger , Manuel Friese
IPC分类号： A61K31/4965 , A61K39/395
CPC分类号： A61K31/4965 , A61K38/17
摘要： The invention relates to a method of treatment or prophylaxis of demyelinating disease, in particular the neurodegenerative phase of demyelinating disease, which comprises administration of an acid sensing ion channel (ASIC) antagonist. The invention also relates to a pharmaceutical composition comprising an ASIC antagonist in combination with an additional therapeutic agent, in particular an anti-inflammatory or immunmodulatory agent.
摘要翻译： 本发明涉及治疗或预防脱髓鞘疾病，特别是脱髓鞘疾病的神经变性期的方法，其包括施用酸感应离子通道（ASIC）拮抗剂。 本发明还涉及包含与另外的治疗剂，特别是抗炎或免疫调节剂组合的ASIC拮抗剂的药物组合物。
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