发明申请
- 专利标题： QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS
- 专利标题（中）： 喹诺酮衍生物作为激酶抑制剂
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申请号： US12471280申请日： 2009-05-22
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公开(公告)号： US20100113468A1公开(公告)日： 2010-05-06
- 发明人: Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
- 申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
- 申请人地址： US MA Cambridge JP Tokyo
- 专利权人： Millennium Pharmaceuticals, Inc.,Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人： Millennium Pharmaceuticals, Inc.,Kyowa Hakko Kogyo Co., Ltd.
- 当前专利权人地址： US MA Cambridge JP Tokyo
- 主分类号： A61K31/497
- IPC分类号： A61K31/497
摘要：
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
公开/授权文献
- US08324205B2 Quinazoline derivatives as kinase inhibitors 公开/授权日：2012-12-04
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