利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

49 条记录 (耗时 0.035 秒)

    Quinazoline derivatives as kinase inhibitors
    2.
    发明授权
    Quinazoline derivatives as kinase inhibitors 失效
    喹唑啉衍生物作为激酶抑制剂

    公开(公告)号：US08324205B2

    公开(公告)日：2012-12-04

    申请号：US12471280

    申请日：2009-05-22

    申请人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    发明人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    IPC分类号： A61K31/535 ,  A61K31/497

    CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管 重建，癌症和肾小球硬化症。

    Light emitting diode including a cover covering a light emitting diode element
    3.
    发明授权
    Light emitting diode including a cover covering a light emitting diode element 失效
    发光二极管包括覆盖发光二极管元件的盖

    公开(公告)号：US07265486B2

    公开(公告)日：2007-09-04

    申请号：US10901222

    申请日：2004-07-29

    申请人： Toshinobu Yoko ,  Masahide Takahashi ,  Kenji Matsuno

    发明人： Toshinobu Yoko ,  Masahide Takahashi ,  Kenji Matsuno

    IPC分类号： H05B33/04 ,  H05B33/00

    CPC分类号： C08L83/04 ,  C08G77/20 ,  C08G77/70 ,  H01L33/56 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/48257 ,  H01L2924/00014 ,  H01L2924/00

    摘要： In an LED (Light Emitting Diode) including a cover covering an LED element, the cover is formed using glass having a composition RnSiO2-n/2. The glass according to the present invention is low melting point glass with a softening temperature of −40° C. to 300° C., melts at lower temperatures compared to conventional glass, and can safely form the cover without damaging the LED element. Since glass has better moisture shield performance and resistance to light compared to epoxy resins, the cover is formed using glass, and consequently deterioration of the LED element and a phosphor caused by moisture is reduced, deterioration of the cover caused by light is reduced, and changes in color and luminous intensity are restrained.

    摘要翻译： 在包括覆盖LED元件的盖的LED（发光二极管）中，使用具有组成R n SiO 2 -n / 2/2的玻璃形成盖。 根据本发明的玻璃是与常规玻璃相比软化温度为-40℃至300℃的低熔点玻璃，在较低温度下熔化，并且可以安全地形成该盖而不损坏该LED元件。 由于与环氧树脂相比，玻璃具有更好的防潮性能和耐光性，所以使用玻璃形成盖，因此降低了LED元件和由水分引起的荧光体的劣化，降低了由光引起的盖的劣化，以及 颜色和发光强度的变化受到限制。

    Quinazoline derivatives as kinase inhibitors
    4.
    发明授权
    Quinazoline derivatives as kinase inhibitors 失效
    喹唑啉衍生物作为激酶抑制剂

    公开(公告)号：US06982266B2

    公开(公告)日：2006-01-03

    申请号：US10344736

    申请日：2001-08-17

    申请人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    发明人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    IPC分类号： A01K31/675 ,  A01K31/517 ,  C07D43/02 ,  C07D239/72

    CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法 ，血管重构，癌症和肾小球硬化症。

    Nitrogenous heterocylic compounds
    5.
    发明授权
    Nitrogenous heterocylic compounds 失效
    含氮杂环化合物

    公开(公告)号：US06956039B2

    公开(公告)日：2005-10-18

    申请号：US10344737

    申请日：2001-08-17

    申请人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    发明人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

    IPC分类号： A61P35/00 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D487/00

    CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管 重建，癌症和肾小球硬化症。

    Manipulation of non-terminally differentiated cells using the Notch pathway
    6.
    发明申请
    Manipulation of non-terminally differentiated cells using the Notch pathway 审中-公开
    使用Notch途径操纵非终末分化细胞

    公开(公告)号：US20050158859A1

    公开(公告)日：2005-07-21

    申请号：US10746237

    申请日：2003-12-22

    申请人： Spyridon Artavanis-Tsakonas ,  Mark Fortini ,  Kenji Matsuno

    发明人： Spyridon Artavanis-Tsakonas ,  Mark Fortini ,  Kenji Matsuno

    IPC分类号： A61K35/12 ,  A61K38/00 ,  C07K14/47 ,  C12N5/00 ,  C12N5/07 ,  A61K48/00 ,  C12N5/08 ,  C12N15/85

    CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  C12N5/0018 ,  C12N5/0601 ,  C12N2501/42

    摘要： The present invention is directed to methods for the expansion of non-terminally differentiated cells (“precursor cells”) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.

    摘要翻译： 本发明涉及使用Notch功能的激动剂来扩增非终末分化的细胞（“前体细胞”）的方法，通过抑制细胞的分化而不抑制增殖（有丝分裂活性），使得扩增的非 - 得到终末分化的细胞。 细胞优选是干细胞或祖细胞。 这些扩展的细胞可用于细胞替代疗法以提供所需的细胞群体并有助于患病和/或损伤组织的再生。 扩增的细胞群体也可以重组并用于基因治疗，或可用于提供与特定前体细胞或其后代细胞相关的功能。

    Light emitting diode
    7.
    发明申请
    Light emitting diode 失效
    发光二极管

    公开(公告)号：US20050023540A1

    公开(公告)日：2005-02-03

    申请号：US10901222

    申请日：2004-07-29

    申请人： Toshinobu Yoko ,  Masahide Takahashi ,  Kenji Matsuno

    发明人： Toshinobu Yoko ,  Masahide Takahashi ,  Kenji Matsuno

    IPC分类号： H01L33/50 ,  C08L83/04 ,  H01L27/15 ,  H01L33/56

    CPC分类号： C08L83/04 ,  C08G77/20 ,  C08G77/70 ,  H01L33/56 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/48257 ,  H01L2924/00014 ,  H01L2924/00

    摘要： In an LED (Light Emitting Diode) including a cover covering an LED element, the cover is formed using glass having a composition RnSiO2−n/2. The glass according to the present invention is low melting point glass with a softening temperature of −40° C. to 300° C., melts at lower temperatures compared to conventional glass, and can safely form the cover without damaging the LED element. Since glass has better moisture shield performance and resistance to light compared to epoxy resins, the cover is formed using glass, and consequently deterioration of the LED element and a phosphor caused by moisture is reduced, deterioration of the cover caused by light is reduced, and changes in color and luminous intensity are restrained.

    摘要翻译： 在包括覆盖LED元件的盖的LED（发光二极管）中，使用具有RnSiO 2 -n / 2组成的玻璃形成该盖。 根据本发明的玻璃是与常规玻璃相比软化温度为-40℃至300℃的低熔点玻璃，在较低温度下熔化，并且可以安全地形成该盖而不损坏该LED元件。 由于与环氧树脂相比，玻璃具有更好的防潮性能和耐光性，所以使用玻璃形成盖，因此降低了LED元件和由水分引起的荧光体的劣化，降低了由光引起的盖的劣化，以及 颜色和发光强度的变化受到限制。

    Nitrogenous heterocyclic compounds
    9.
    发明授权
    Nitrogenous heterocyclic compounds 有权
    含氮杂环化合物

    公开(公告)号：US06423716B1

    公开(公告)日：2002-07-23

    申请号：US09647490

    申请日：2000-09-29

    申请人： Kenji Matsuno ,  Yuji Nomoto ,  Michio Ichimura ,  Shin-ichi Ide ,  Shoji Oda

    发明人： Kenji Matsuno ,  Yuji Nomoto ,  Michio Ichimura ,  Shin-ichi Ide ,  Shoji Oda

    IPC分类号： A61K3150

    CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): wherein W represents 1,4-piperazinediyl, etc.; U represents NR1R2 (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and R2 represents a hydrogen atom, etc. ), OR4, or SR5; V represents an oxygen atom, a sulfur atom, N—R6, or CR7R8, at least one of X, Y and Z represents a nitrogen atom, and the others are the same or different, and each represents a nitrogen atom or C—RA; and D1, D2, D3 and D4 each independently represent C—RB, a nitrogen atom, an oxygen atom, a sulfur atom, etc., optional adjoining two among D1 to D4 are combined to represent a nitrogen atom, N—R2A, an oxygen atom, a sulfur atom, etc., or optional adjoining two selected from D1 to D4 represent C—RB″ (wherein two RB″s are combined to represent substituted or unsubstituted alicyclic alkene, substituted or unsubstituted pyrrole, substituted or unsubstituted pyrazole, etc.; or pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及由式（I）表示的含氮杂环化合物：其中W表示1,4-哌嗪二基等; U表示NR1R2（其中R1表示氢原子，取代或未取代的烷基等; R2表示氢原子等），OR4或SR5; V表示氧原子，硫原子，N-R6或CR7R8，X，Y和Z中的至少一个表示氮原子，其它相同或不同，表示氮原子或C-RA ; D1，D2，D3和D4各自独立地表示C-RB，氮原子，氧原子，硫原子等，D1〜D4中任意相邻的2个相互组合，表示氮原子，N-R2A， 氧原子，硫原子等，或选自D1〜D4中任意相邻的2个表示C-RB“（其中两个RB'组合以代表取代或未取代的脂环族烯烃，取代或未取代的吡咯，取代或未取代的 吡唑等;或其药学上可接受的盐。