发明申请
- 专利标题： MODELS OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND METHODS OF USE THEREOF
- 专利标题（中）： 血栓性红血球病的模型及其使用方法
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申请号： US12606884申请日： 2009-10-27
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公开(公告)号： US20100115637A1公开(公告)日： 2010-05-06
- 发明人: Hans-Peter Schwarz , Eva-Maria Muchitsch , Peter Turecek
- 申请人： Hans-Peter Schwarz , Eva-Maria Muchitsch , Peter Turecek
- 申请人地址： US IL Deerfield CH Glattpark (Opfikon)
- 专利权人： BAXTER INTERNATIONAL INC.,BAXTER HEALTHCARE S.A.
- 当前专利权人： BAXTER INTERNATIONAL INC.,BAXTER HEALTHCARE S.A.
- 当前专利权人地址： US IL Deerfield CH Glattpark (Opfikon)
- 主分类号： G01N33/00
- IPC分类号： G01N33/00 ; A01K67/00
摘要：
The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.
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