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公开(公告)号：US08969524B2
公开(公告)日：2015-03-03
申请号：US13283452
申请日：2011-10-27
申请人： Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人： Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
IPC分类号： A61K38/37 , C07K14/745 , G01N33/50
CPC分类号： C07K14/755 , A61K38/37 , C07K2319/00 , C12P21/00 , G01N33/505 , G01N33/56977
摘要： The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII-specific CD4+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.
摘要翻译： 本发明涉及可用于降低针对FVIII的免疫应答或诱导对例如血友病A的患者对人FVIII的耐受性的肽。此外，该肽可用于免疫诊断目的以检测FVIII-特异性CD4 + T细胞在替代治疗期间和免疫耐受诱导治疗期间监测血友病A患者。
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2.发明授权Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH 有权在弱酸性至中性pH下通过组氨酸的水性制剂稳定免疫球蛋白公开(公告)号：US08795658B2
公开(公告)日：2014-08-05
申请号：US13235314
申请日：2011-09-16
申请人： Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
发明人： Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Wolfgang Teschner , Hans-Peter Schwarz
IPC分类号： A61K39/395 , A61K47/02 , A61K47/18 , A61K9/00
CPC分类号： A61K39/39591 , A61K9/0019 , A61K47/02 , A61K47/183
摘要： The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration.
摘要翻译： 除其他方面之外，本发明提供了在轻度酸性至中性pH下具有组氨酸的免疫球蛋白的储存稳定水性制剂。 本发明还提供了通过在轻度酸性至中性pH下配制组氨酸来稳定免疫球蛋白组合物的方法。 有利地，本文提供的方法和制剂允许稳定的免疫球蛋白水溶液组合物，其具有适用于胃肠外给药的中等pH至中性pH。
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3.发明授权Kit for measuring the thrombin generation in a sample of a patient's blood or plasma 有权用于测量患者血液或血浆样品中凝血酶产生的试剂盒公开(公告)号：US08735086B2
公开(公告)日：2014-05-27
申请号：US13539154
申请日：2012-06-29
IPC分类号： C12Q1/56
CPC分类号： A61K31/66 , C12Q1/56 , G01N33/86 , G01N2333/745
摘要： The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
摘要翻译： 本发明提供了一种用于测量患者血液或血浆样品或凝血因子样品中的凝血酶产生的试剂盒。 该试剂盒含有冻干组织因子/磷脂复合物和含有凝血酶底物和CaCl 2的冻干混合物。 本发明还提供了用于制备试剂盒的试剂的方法。 该试剂盒可以用于测量样品中凝血酶产生的方法，其中可以检测凝血酶产生动力学的变化，例如在将抑制剂旁路剂施用于已经开发出外源凝血因子的抑制剂的患者之后 作为因子VIII。
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4.发明授权Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors 有权生物流体中微生物灭活的方法，流经反应器的方法和控制光总剂量以有效灭活间歇反应器中的微生物的方法公开(公告)号：US08377375B2
公开(公告)日：2013-02-19
申请号：US13100570
申请日：2011-05-04
申请人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
发明人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
摘要翻译： 本发明涉及一种用于确定来自一种或多种光源的有效剂量的单色或多色光以灭活存在于生物流体中，优选非透明流体中的微生物的方法。 此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。 此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。 本发明还提供一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭活间歇反应器中存在于生物流体中的微生物。
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5.发明申请MODIFIED RECOMBINANT FACTOR VIII AND VON WILLEBRAND FACTOR AND METHODS OF USE 审中-公开改性重组因子VIII和VON WILLEBRAND因子及其使用方法公开(公告)号：US20120322737A1
公开(公告)日：2012-12-20
申请号：US13452612
申请日：2012-04-20
申请人： Hans-Peter Schwarz , Peter Turecek
发明人： Hans-Peter Schwarz , Peter Turecek
CPC分类号： A61K38/37 , A61K47/60 , A61K47/61 , C07K14/755 , C08G65/329 , C08H1/00 , C08L63/00 , C08L2203/02
摘要： The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.
摘要翻译： 本发明提供了通过抑制与间隙受体的相互作用来增加凝血蛋白的存活的新方法。 本发明还提供了制备抑制凝血蛋白清除受体的组合物的方法。 共轭凝血蛋白，包括其组合物和制剂，也由本发明提供。
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公开(公告)号：US20120225487A1
公开(公告)日：2012-09-06
申请号：US13410114
申请日：2012-03-01
IPC分类号： G01N21/31
CPC分类号： G01N33/50 , G01N33/92 , G01N2400/00
摘要： The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination.
摘要翻译： 本发明涉及一种测定含蛋白质样品中的聚山梨醇酯的方法。 本发明的方法涉及通过碱水解进行样品预处理，然后进行比色测定。
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7.发明授权Detection of antibody that binds to water soluble polymer-modified polypeptides 有权检测结合水溶性聚合物修饰多肽的抗体公开(公告)号：US08216793B2
公开(公告)日：2012-07-10
申请号：US12786641
申请日：2010-05-25
申请人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
IPC分类号： G01N33/566
CPC分类号： G01N33/6854
摘要： The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
摘要翻译： 本发明提供了检测个体抗体抗体的分析方法。 所述方法包括使来自个体的样品与水溶性聚合物修饰的载体接触并检测抗体与水溶性聚合物修饰的载体上的水溶性聚合物的结合，其中结合指示抗体存在于聚合物修饰的水 多肽。 可以对水溶性聚合物如聚乙二醇，聚唾液酸，葡聚糖，羟烷基淀粉或羟乙基淀粉检测抗体。 当检测到对水溶性聚合物聚乙二醇的抗体时，用非线性聚乙二醇衍生物修饰载体。
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8.发明授权Methods for differentiating plasma-derived protein from recombinant protein in a sample 有权在样品中从重组蛋白质中分离血浆来源的蛋白质的方法公开(公告)号：US08114633B2
公开(公告)日：2012-02-14
申请号：US12341098
申请日：2008-12-22
申请人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
发明人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.
摘要翻译： 本发明一般涉及当血浆蛋白质和重组蛋白质基本上相同的蛋白质时，基于蛋白质糖基化的差异，在样品中检测和定量血浆衍生的蛋白质和重组蛋白质的方法。
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9.发明申请REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE 有权用精细二氧化硅二氧化硅处理去除丝氨酸蛋白公开(公告)号：US20110293594A1
公开(公告)日：2011-12-01
申请号：US13117028
申请日：2011-05-26
申请人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
发明人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
IPC分类号： A61K38/46 , C07K1/36 , A61K38/17 , A61P7/00 , C12N9/18 , A61K38/57 , A61K38/38 , C07K14/47 , C07K1/14 , C07K14/76
CPC分类号： C07K16/065 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K39/39525 , A61K47/183 , B01D15/12 , B01D15/362 , B01D15/363 , B01D15/424 , C07K1/30 , C07K1/36
摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
摘要翻译： 本发明提供了用于降低血浆来源的蛋白质组合物的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的新方法。 还提供了制备具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生蛋白质组合物的方法。 在其它方面中，本发明提供具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生蛋白质的水性和冻干组合物。 还有其它方面包括用于治疗，控制和/或预防疾病的方法，所述疾病包括施用具有降低的丝氨酸蛋白酶或丝氨酸蛋白酶酶原含量的血浆衍生的蛋白质组合物。
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10.发明授权Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors 有权生物流体中微生物灭活的方法，流经反应器的方法和控制光总剂量以有效灭活间歇反应器中的微生物的方法公开(公告)号：US07993580B2
公开(公告)日：2011-08-09
申请号：US10924579
申请日：2004-08-24
申请人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
发明人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
摘要翻译： 本发明涉及一种用于确定来自一种或多种光源的有效剂量的单色或多色光以灭活存在于生物流体中，优选非透明流体中的微生物的方法。 此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。 此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。 本发明还提供了一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭菌间歇反应器中存在于生物流体中的微生物。
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