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1.发明申请公开(公告)号：US20100115637A1
公开(公告)日：2010-05-06
申请号：US12606884
申请日：2009-10-27
CPC分类号： A61K49/0008 , A01K67/027 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0325 , A01K2267/0381 , C12N15/8509
摘要： The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.
摘要翻译： 本发明涉及用于测试治疗凝血障碍的各种药剂的动物模型的开发。 更具体地，本发明涉及在各种小鼠品系中使用超大分子量多聚体维生素B因子（VWF）以诱导血小板减少性紫癜（TTP）样症状，用于开发TTP小鼠模型。 本发明还提供了产生用于鉴定有效治疗TTP的生物活性化合物的动物疾病模型和筛选方法。
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2.发明授权公开(公告)号：US09587249B2
公开(公告)日：2017-03-07
申请号：US12606884
申请日：2009-10-27
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： A61K49/0008 , A01K67/027 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0325 , A01K2267/0381 , C12N15/8509
摘要： The invention relates to the development of an animal model for testing various agents in the treatment of a clotting disorder. More specifically, the invention relates to the use of ultra-large molecular weight multimers of von Willebrand factor (VWF) in various mouse strains to induce thrombotic thrombocytopenic purpura (TTP)-like symptoms for the development of a mouse model of TTP. The invention also provides methods for generating such animal disease models and screening methods for identifying biologically active compounds which are effective in the treatment of TTP.
摘要翻译： 本发明涉及用于测试治疗凝血障碍的各种药剂的动物模型的开发。 更具体地，本发明涉及在各种小鼠品系中使用超大分子量多聚体维生素B因子（VWF）以诱导血小板减少性紫癜（TTP）样症状，用于开发TTP的小鼠模型。 本发明还提供了产生用于鉴定有效治疗TTP的生物活性化合物的动物疾病模型和筛选方法。
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3.发明申请Transgenic Mouse Lacking Endogenous FVIII and VWF - A Model of Hemophilia A 审中-公开转基因小鼠缺乏内源性FVIII和VWF - A型血友病A公开(公告)号：US20110072524A1
公开(公告)日：2011-03-24
申请号：US12850243
申请日：2010-08-04
IPC分类号： A61K38/36 , A01K67/00 , A01K67/027 , A61K49/00 , A61P7/04
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/052 , A01K2217/054 , A01K2217/072 , A01K2227/105 , A01K2267/03
摘要： The present invention relates, generally, to a transgenic non-human animal model of hemophilia A, wherein the transgenic animal is deficient in endogenous Factor VIII and endogenous von Willebrand Factor, and methods to treat hereditary or acquired hemophilia A or von Willebrand Disease (VWD) by administration of exogenous human VWF.
摘要翻译： 本发明通常涉及血友病A的转基因非人动物模型，其中转基因动物缺乏内源因子VIII和内源性血管性血友病因子，以及治疗遗传性或获得性血友病A或血管性血友病（VWD）的方法 ）通过外源人VWF的施用。
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