This CTI Valve manifold of this invention creates a wheel-manifold-CTI Valve combination such that an air passageway coming from the wheel hub through the manifold brings air to the valve, and an airway from the valve through the manifold provides air to the tire cavity, preferably via an air passageway in the wheel. The manifold also allows for the CTI valve to deflate the tire, a typical operational requirement for central tire inflation systems.