Invention Application
- Patent Title: QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON
- Patent Title (中): 基于快速溶解组合物和片剂
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Application No.: US12730339Application Date: 2010-03-24
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Publication No.: US20100178353A1Publication Date: 2010-07-15
- Inventor: Naima MEZAACHE , Steven E. Frisbee , Patrick B. Woodall , Mark R. Herman
- Applicant: Naima MEZAACHE , Steven E. Frisbee , Patrick B. Woodall , Mark R. Herman
- Applicant Address: BB St. Michael
- Assignee: BIOVAIL LABORATORIES INTERNATIONAL S.R.L.
- Current Assignee: BIOVAIL LABORATORIES INTERNATIONAL S.R.L.
- Current Assignee Address: BB St. Michael
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K31/138 ; A61K31/4525 ; A61K31/437 ; A61P25/24

Abstract:
The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.
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