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    Quick dissolve compositions and tablets based thereon
    1.
    发明授权
    Quick dissolve compositions and tablets based thereon 有权
    快速溶解组合物和片剂

    公开(公告)号：US07815937B2

    公开(公告)日：2010-10-19

    申请号：US10176135

    申请日：2002-06-21

    申请人： Naima Mezaache ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman ,  Djelila Mezaache

    发明人： Naima Mezaache ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman ,  Djelila Mezaache

    IPC分类号： A61K9/20

    CPC分类号： A61K9/1617 ,  A61K9/0056 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/2095 ,  A61K9/5026 ,  A61K9/5042 ,  A61K31/366 ,  A61K31/426 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38

    摘要： The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

    摘要翻译： 本发明提供了一种组合物，其可用于制备能够在少于40秒内溶解于口中的口服剂型，而不需要常规的超级崩解剂并具有小于1％的脆性; 其中所述组合物包括液体微粒和赋形剂。 根据本发明优选的赋形剂组合物包含直接可压缩的无机盐; 纤维素衍生物或直接可压缩的无机盐和纤维素衍生物的组合。 优选地，液体颗粒和赋形剂组合的比例使得当组合物被压缩以获得硬度为20至50N的剂型时，活性成分基本保持在微球内。本发明的组合物允许 制造具有改善的硬度和脆性的口服剂量。

    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON
    3.
    发明申请
    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON 审中-公开
    基于快速溶解组合物和片剂

    公开(公告)号：US20100178353A1

    公开(公告)日：2010-07-15

    申请号：US12730339

    申请日：2010-03-24

    申请人： Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    发明人： Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    IPC分类号： A61K9/14 ,  A61K31/138 ,  A61K31/4525 ,  A61K31/437 ,  A61P25/24

    CPC分类号： A61K9/1635 ,  A61K9/0056 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/2081 ,  A61K9/5026 ,  A61K31/366 ,  A61K31/426

    摘要： The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

    摘要翻译： 本发明提供了一种组合物，其可用于制备能够在少于40秒内溶解于口中的口服剂型，而不需要常规的超级崩解剂并具有小于1％的脆性; 其中所述组合物包括液体微粒和赋形剂。 根据本发明优选的赋形剂组合物包含直接可压缩的无机盐; 纤维素衍生物或直接可压缩的无机盐和纤维素衍生物的组合。 优选地，液体颗粒和赋形剂组合的比例使得当组合物被压缩以获得硬度为20至50N的剂型时，活性成分基本保持在微球内。本发明的组合物允许 制造具有改善的硬度和脆性的口服剂量。

    Liquiflash particles and method of making same
    5.
    发明授权
    Liquiflash particles and method of making same 失效
    Liquiflash颗粒及其制备方法

    公开(公告)号：US5849223A

    公开(公告)日：1998-12-15

    申请号：US453053

    申请日：1995-05-26

    申请人： Garry L. Myers ,  Robert K. Yang ,  Mark R. Herman

    发明人： Garry L. Myers ,  Robert K. Yang ,  Mark R. Herman

    IPC分类号： A61J3/02 ,  A61J1/00 ,  A61J7/00 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/50 ,  B01J2/00 ,  B01J2/02 ,  A61K9/14

    CPC分类号： A61J7/0015 ,  A61J1/00 ,  A61K9/1688 ,  A61K9/1694 ,  A61K9/2081 ,  A61K9/2095 ,  A61K9/5026 ,  B01J2/00 ,  B01J2/02

    摘要： The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.

    摘要翻译： 本发明是通过使有机原料经历液化条件来制备离散颗粒的方法，由此原料从固体瞬间转变成液态至固体。 液体是一种瞬态条件，其中原料具有基本上无阻碍的内部流动。 剪切力被赋予液体原料，其量足以分离出微量的原料。 微小的团块固化为离散粒子。 本发明还包括由该方法产生的独特产物，例如单分散的微球产物和由其制备的包衣颗粒。

    Liquiflash particles and method of making same
    7.
    发明授权
    Liquiflash particles and method of making same 失效
    Liquiflash颗粒及其制备方法

    公开(公告)号：US5683720A

    公开(公告)日：1997-11-04

    申请号：US330412

    申请日：1994-10-28

    申请人： Garry L. Myers ,  Robert K. Yang ,  Mark R. Herman

    发明人： Garry L. Myers ,  Robert K. Yang ,  Mark R. Herman

    IPC分类号： A61J3/02 ,  A61J1/00 ,  A61J7/00 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/50 ,  B01J2/00 ,  B01J2/02 ,  A61K9/14

    CPC分类号： A61J7/0015 ,  A61J1/00 ,  A61K9/1688 ,  A61K9/1694 ,  A61K9/2081 ,  A61K9/2095 ,  A61K9/5026 ,  B01J2/00 ,  B01J2/02

    摘要： The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.

    摘要翻译： 本发明是通过使有机原料经历液化条件来制备离散颗粒的方法，由此原料从固体瞬间转变成液态至固体。 液体是一种瞬态条件，其中原料具有基本上无阻碍的内部流动。 剪切力被赋予液体原料，其量足以分离出微量的原料。 微小的团块固化为离散粒子。 本发明还包括由该方法产生的独特产物，例如单分散的微球产物和由其制备的包衣颗粒。