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16 条记录 (耗时 0.044 秒)

    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON
    2.
    发明申请
    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON 审中-公开
    基于快速溶解组合物和片剂

    公开(公告)号：US20100178353A1

    公开(公告)日：2010-07-15

    申请号：US12730339

    申请日：2010-03-24

    申请人： Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    发明人： Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    IPC分类号： A61K9/14 ,  A61K31/138 ,  A61K31/4525 ,  A61K31/437 ,  A61P25/24

    CPC分类号： A61K9/1635 ,  A61K9/0056 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/2081 ,  A61K9/5026 ,  A61K31/366 ,  A61K31/426

    摘要： The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

    摘要翻译： 本发明提供了一种组合物，其可用于制备能够在少于40秒内溶解于口中的口服剂型，而不需要常规的超级崩解剂并具有小于1％的脆性; 其中所述组合物包括液体微粒和赋形剂。 根据本发明优选的赋形剂组合物包含直接可压缩的无机盐; 纤维素衍生物或直接可压缩的无机盐和纤维素衍生物的组合。 优选地，液体颗粒和赋形剂组合的比例使得当组合物被压缩以获得硬度为20至50N的剂型时，活性成分基本保持在微球内。本发明的组合物允许 制造具有改善的硬度和脆性的口服剂量。

    Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith
    3.
    发明授权
    Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith 失效
    控制释放，低剂量阿司匹林制剂及其治疗血管闭塞性疾病的方法

    公开(公告)号：US4970081A

    公开(公告)日：1990-11-13

    申请号：US293832

    申请日：1989-01-03

    申请人： Steven E. Frisbee

    发明人： Steven E. Frisbee

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/32 ,  A61K31/60

    CPC分类号： A61K9/2081 ,  A61K31/60

    摘要： An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and disintegrants is also provided, as are processes for preparing the tablets and granules and methods for their use in the treatment of vascular occlusive diseases.

    摘要翻译： 提供了一种水性制剂，用于涂覆阿司​​匹林颗粒以提供可压缩成片剂的颗粒，并且在5-8小时内延长释放速率为5至15mg /小时的释放动力学。 涂料配方优选由丙烯酸酯/甲基丙烯酸酯共聚物，羟丙基甲基纤维素，氯化钠和滑石组成。 还提供了由包衣颗粒，填充剂颗粒，赋形剂，粘合剂和崩解剂组成的薄膜包衣片剂，以及制备片剂和颗粒的方法及其用于治疗血管闭塞性疾病的方法。

    Oral sustained-release drug compositions
    5.
    发明授权
    Oral sustained-release drug compositions 失效
    口服持续释放药物组合物

    公开(公告)号：US5213811A

    公开(公告)日：1993-05-25

    申请号：US759347

    申请日：1991-09-13

    申请人： Steven E. Frisbee ,  Gregg Stetsko ,  Margaret A. Lawton

    发明人： Steven E. Frisbee ,  Gregg Stetsko ,  Margaret A. Lawton

    IPC分类号： A61K9/50 ,  A61K9/54

    CPC分类号： A61K9/5078 ,  Y10S514/962 ,  Y10S514/963 ,  Y10S514/964

    摘要： Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or hydroxypropyl cellulose and a plasticizer selected from triacetin, diacetylated monoglycerides, glycerin, propylene glycol, polyethylene glycol, diethyl phthalate and triethyl citrate or a mixture of two or more thereof and a second coating of high-viscosity ethylcellulose, low-viscosity ethylcellulose, hydroxypropyl cellulose, polyvinyl acetate phthalate and a plasticizer selected from diacetylated monoglycerides and triacetin or a mixture thereof and optionally coated with additional first coating and capsules filled therewith and method of preparation thereof are disclosed.

    摘要翻译： 用药物的第一次包被的糖或糖/淀粉珠，例如1,2-二氢-6-（低级烷基）-2-氧代-5-（4-吡啶基） - 烟腈（米力农），羟丙基甲基纤维素或 羟丙基纤维素和增塑剂，其选自三醋精，二乙酰化单酸甘油酯，甘油，丙二醇，聚乙二醇，邻苯二甲酸二乙酯和柠檬酸三乙酯或其两种或更多种的混合物和第二层高粘度乙基纤维素，低粘度乙基纤维素，羟丙基纤维素 ，聚乙酸乙烯酯邻苯二甲酸酯和选自二乙酰化单甘油酯和三醋精或其混合物的增塑剂，并任选地涂覆有另外的第一涂层和填充的胶囊及其制备方法。

    PHARMACEUTICAL COMPOSITIONS
    6.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号：US20100055133A1

    公开(公告)日：2010-03-04

    申请号：US12540144

    申请日：2009-08-12

    申请人： Andrew John Duffield ,  Graham Jackson ,  Steven E. Frisbee

    发明人： Andrew John Duffield ,  Graham Jackson ,  Steven E. Frisbee

    IPC分类号： A61K39/08 ,  A61K31/435 ,  A61K31/5513 ,  A61P25/00

    CPC分类号： A61K45/06 ,  A61K9/2054 ,  A61K31/4745

    摘要： The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonlus, dystoniia and/or Tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder.

    摘要翻译： 本发明提供一种药物组合物，其包含丁苯那嗪和释放阻滞剂; 以及治疗过度运动障碍（例如亨廷顿舞蹈病，与亨廷顿舞蹈病，偏头痛，老年性舞蹈病，抽搐障碍，迟发性运动障碍，肌阵挛，肌张力障碍和/或图雷特综合征相关的舞蹈病）的方法。 该方法包括给予有效量的药物组合物一段有效治疗过度运动障碍的时间。

    Quick dissolve compositions and tablets based thereon
    8.
    发明授权
    Quick dissolve compositions and tablets based thereon 有权
    快速溶解组合物和片剂

    公开(公告)号：US07815937B2

    公开(公告)日：2010-10-19

    申请号：US10176135

    申请日：2002-06-21

    申请人： Naima Mezaache ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman ,  Djelila Mezaache

    发明人： Naima Mezaache ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman ,  Djelila Mezaache

    IPC分类号： A61K9/20

    CPC分类号： A61K9/1617 ,  A61K9/0056 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/2095 ,  A61K9/5026 ,  A61K9/5042 ,  A61K31/366 ,  A61K31/426 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38

    摘要： The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

    摘要翻译： 本发明提供了一种组合物，其可用于制备能够在少于40秒内溶解于口中的口服剂型，而不需要常规的超级崩解剂并具有小于1％的脆性; 其中所述组合物包括液体微粒和赋形剂。 根据本发明优选的赋形剂组合物包含直接可压缩的无机盐; 纤维素衍生物或直接可压缩的无机盐和纤维素衍生物的组合。 优选地，液体颗粒和赋形剂组合的比例使得当组合物被压缩以获得硬度为20至50N的剂型时，活性成分基本保持在微球内。本发明的组合物允许 制造具有改善的硬度和脆性的口服剂量。

    System for rendering substantially non-dissoluble bio-affecting agents bio-available
    9.
    发明授权
    System for rendering substantially non-dissoluble bio-affecting agents bio-available 有权
    用于使生物可用的基本上不可溶的生物影响剂呈现的系统

    公开(公告)号：US06391338B1

    公开(公告)日：2002-05-21

    申请号：US09138194

    申请日：1998-08-21

    申请人： Steven E. Frisbee ,  Garry L. Myers ,  Richard C. Fuisz ,  Andrea S. Blake ,  Robert K. Yang

    发明人： Steven E. Frisbee ,  Garry L. Myers ,  Richard C. Fuisz ,  Andrea S. Blake ,  Robert K. Yang

    IPC分类号： A61K926

    CPC分类号： B01J13/04 ,  A01N25/10 ,  A61K9/146 ,  A61K9/70 ,  Y10S514/965

    摘要： The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (“bio-available”) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.

    摘要翻译： 本发明是制备用于递送生物影响剂的系统的方法和由其制备的组合物。 本发明包括在与生物影响剂相容的水溶性聚合物中以增加的能量状态形成生物影响剂的分子分散体。 作为将生物影响剂转化为增加能量条件并在这种条件下在水溶性聚合物中冷冻的结果，生物影响剂在生物系统上可用（“生物可用”） 聚合物的溶解。 已经发现，该方法和组合物对于递送基本上不可溶的药物和其它生物影响成分非常有效。