发明申请
- 专利标题： CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS
- 专利标题（中）： 卡波醇衍生物有助于抑制血管生成
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申请号： US12715651申请日： 2010-03-02
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公开(公告)号： US20100179132A1公开(公告)日： 2010-07-15
- 发明人: Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
- 申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
- 专利权人： PTC Therapeutics, Inc.
- 当前专利权人： PTC Therapeutics, Inc.
- 优先权： USPCT/US2005/008481 20050315
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61K31/497 ; A61K31/437 ; A61K31/506 ; A61K31/496 ; A61K31/5377 ; A61K31/541 ; A61P35/00
摘要：
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
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