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公开(公告)号：US08372860B2
公开(公告)日：2013-02-12
申请号：US12715651
申请日：2010-03-02
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： A61K31/337 , A61K31/4353 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/5513 , G01N2333/475 , G01N2333/515 , A61K2300/00
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血浆和/或肿瘤VEGF水平的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。
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公开(公告)号：US07767689B2
公开(公告)日：2010-08-03
申请号：US11107783
申请日：2005-04-18
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
IPC分类号： A61K31/437 , C07D487/04
CPC分类号： A61K31/337 , A61K31/4353 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/5513 , G01N2333/475 , G01N2333/515 , A61K2300/00
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血浆和/或肿瘤VEGF水平的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。
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公开(公告)号：US20100179132A1
公开(公告)日：2010-07-15
申请号：US12715651
申请日：2010-03-02
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
IPC分类号： A61K31/551 , A61K31/497 , A61K31/437 , A61K31/506 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： A61K31/337 , A61K31/4353 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/5513 , G01N2333/475 , G01N2333/515 , A61K2300/00
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血浆和/或肿瘤VEGF水平的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。
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公开(公告)号：US20100125065A1
公开(公告)日：2010-05-20
申请号：US12506485
申请日：2009-07-21
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
IPC分类号： A61K31/551 , C07D401/14 , A61K31/497 , C07D471/02 , A61K31/437 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D243/08 , C07D417/14 , A61K31/541 , A61P9/00
CPC分类号： A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。
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公开(公告)号：US08367694B2
公开(公告)日：2013-02-05
申请号：US12506485
申请日：2009-07-21
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
IPC分类号： C07D487/14 , A61K31/437
CPC分类号： A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
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公开(公告)号：US07601840B2
公开(公告)日：2009-10-13
申请号：US11079420
申请日：2005-03-15
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang
IPC分类号： C07D487/04 , A61K31/437
CPC分类号： A61K31/506 , A61K31/437 , A61K31/4745 , A61K31/497 , A61K31/5355 , A61K31/541 , A61K31/551 , C07D471/04
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。
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7.发明授权公开(公告)号：US08940896B2
公开(公告)日：2015-01-27
申请号：US10592761
申请日：2005-03-15
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson
IPC分类号： C07D235/02 , A61K31/4166 , C07D221/18 , C07D239/26 , C07D265/30 , C07D307/78 , C07D317/48 , C07D241/04
CPC分类号： A61K31/4166 , C07D221/18 , C07D235/02 , C07D239/26 , C07D241/04 , C07D265/30 , C07D307/78 , C07D317/48
摘要： In accordance with the present invention, tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的四环caboline衍生物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF生成，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的这些化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。
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8.发明申请公开(公告)号：US20080182866A1
公开(公告)日：2008-07-31
申请号：US10592761
申请日：2005-03-15
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson
IPC分类号： A61K31/437 , A61P43/00
CPC分类号： A61K31/4166 , C07D221/18 , C07D235/02 , C07D239/26 , C07D241/04 , C07D265/30 , C07D307/78 , C07D317/48
摘要： In accordance with the present invention, tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的四环caboline衍生物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF生成，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的这些化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。
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