发明申请
US20100190162A1 METHODS OF USING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE TL1A GENE TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE
审中-公开
使用单核苷酸多态性在TL1A基因中预测或诊断炎症性皮肤病的方法
- 专利标题： METHODS OF USING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE TL1A GENE TO PREDICT OR DIAGNOSE INFLAMMATORY BOWEL DISEASE
- 专利标题（中）： 使用单核苷酸多态性在TL1A基因中预测或诊断炎症性皮肤病的方法
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申请号： US12528055申请日： 2008-02-26
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公开(公告)号： US20100190162A1公开(公告)日： 2010-07-29
- 发明人: Jerome I. Rotter , Kent D. Taylor , Marla Dubinsky , Stephan R. Targan
- 申请人： Jerome I. Rotter , Kent D. Taylor , Marla Dubinsky , Stephan R. Targan
- 申请人地址： US CA Los Angeles
- 专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人： CEDARS-SINAI MEDICAL CENTER
- 当前专利权人地址： US CA Los Angeles
- 国际申请： PCT/US08/55020 WO 20080226
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
This invention provides methods of diagnosing or predicting susceptibility to Inflammatory Bowel Disease by determining the presence or absence of genetic variants in the TL1A gene. In one embodiment, a method of the invention is practiced by determining the presence or absence of TL1A production following Fc-gamma-R activation. In another embodiment, the invention provides methods of treatment of inflammatory bowel disease by inhibition of TL1A.
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