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发明申请
US20100204206A1 Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them 有权
二（异）芳基环己烷衍生物，其制备方法，用途和包含它们的药物组合物

Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them
摘要：
Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising themThe present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
摘要（中）：

二（杂）芳基环己烷衍生物，其制备方法及用途及其组合物本发明涉及式I的二（异）芳基环己烷衍生物，其中Ar 1，Ar 2，R 1和R 2具有权利要求中所示的含义。 式I的化合物是抑制心肌中ATP敏感钾通道的有价值的药物活性化合物，并且适用于例如治疗心血管系统疾病如心律失常或心脏收缩力降低， 例如，可能发生在冠心病，心功能不全或心肌病。 特别是适用于预防心源性猝死。 本发明还涉及用于制备式I化合物的方法和中间体，其用途和包含它们的药物组合物。

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