发明申请
- 专利标题： GALENICAL FORMULATIONS OF ORGANIC COMPOUNDS
- 专利标题（中）： 有机化合物的制剂配方
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申请号： US12678877申请日： 2008-09-24
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公开(公告)号： US20100209480A1公开(公告)日： 2010-08-19
- 发明人: Ralf Altenburger , Maggy B. Saunier , Nicole Bargenda , Michael A. Bock , Sabine Adler , Bruno Buss , Catherine Curdy , Indrajit Ghosh , Stefan Hirsch , Patrice F. Keller , Charu Kochhar , Shoufeng Li , Nicoletta Loggia , Amol S. Matharu , Julien Taillemite , Wei-Qin Tong , Sudha Vippagunta , Hong Wen , Marie-Christine Wolf , Jay P. Lakshman , James Kowalski
- 申请人： Ralf Altenburger , Maggy B. Saunier , Nicole Bargenda , Michael A. Bock , Sabine Adler , Bruno Buss , Catherine Curdy , Indrajit Ghosh , Stefan Hirsch , Patrice F. Keller , Charu Kochhar , Shoufeng Li , Nicoletta Loggia , Amol S. Matharu , Julien Taillemite , Wei-Qin Tong , Sudha Vippagunta , Hong Wen , Marie-Christine Wolf , Jay P. Lakshman , James Kowalski
- 国际申请： PCT/US08/77416 WO 20080924
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61K9/70 ; A61K9/48 ; A61K9/24 ; A61K9/14 ; A61P13/12 ; A61P9/10 ; A61P9/04 ; A61P9/12 ; B29B9/06
摘要：
The present invention relates to a pharmaceutical oral fixed dose combination comprising a) a therapeutically effective amount of Aliskiren, or a pharmaceutically acceptable salt thereof, b) a therapeutically effective amount of Valsartan, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical oral fixed dose combination shows an in vitro dissolution of component a) of 80% or less after 10 minutes and 98% or less after 20 minutes, and a dissolution profile of component b) of 25% or more after 30 minutes, and 40% or more after 60 minutes at pH 4.5.
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