发明申请
- 专利标题： METHOD FOR PREPARING ANTIBODY MONOLAYERS WHICH HAVE CONTROLLED ORIENTATION USING PEPTIDE HYBRID
- 专利标题（中）： 使用肽混合物制备具有控制方向的抗体单体的方法
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申请号： US12679982申请日： 2007-10-18
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公开(公告)号： US20100209945A1公开(公告)日： 2010-08-19
- 发明人: Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
- 申请人： Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
- 申请人地址： KR Daejeon
- 专利权人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人地址： KR Daejeon
- 优先权： KR10-2007-0098852 20071001
- 国际申请： PCT/KR2007/005106 WO 20071018
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K7/08 ; C07K7/06 ; G01N1/31
摘要：
The present invention relates to a method for preparing an protein monolayer using a peptide hybrid for protein immobilization, more precisely a peptide hybrid for protein immobilization which has improved solubility by introducing a PEG linker and a proper reaction group to the oligopeptide having specific affinity to selected types of proteins and is designed to provide enough space between solid substrates and proteins immobilized, whereby various solid substrates treated by the hybrid catch specific proteins effectively on. The peptide hybrid for protein immobilization of the present invention facilitates the control of orientation of an antibody on various solid surfaces and immobilization of various antibodies of different origins or having different isotypes with different affinity. Therefore, the surface treatment technique using the peptide hybrid of the invention can be effectively used for the production of various immunosensors and immune chips.
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