公开(公告)号：US12226395B2

公开(公告)日：2025-02-18

申请号：US17811327

申请日：2022-07-08

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Won Gon Kim ,  Baek Soo Han ,  Jeong Su Byun ,  Van Minh Nguyen ,  Ha Young Choi

IPC: A61K31/36 ,  A23L33/105 ,  A61K31/232

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof. Specifically, the diterpene of the present invention can prevent or treat neurodegenerative diseases caused by inhibition of Nurr1 activity by activating Nurr1 and inhibiting the inflammatory response.

公开(公告)号：US12110325B2

公开(公告)日：2024-10-08

申请号：US18154597

申请日：2023-01-13

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Se Mi Kim ,  Jung Weon Lee ,  Dongjoon Ko ,  Junghwa Yoon ,  Eunmi Kim ,  Seo Hee Nam ,  Eun Ae Shin

IPC: C07K16/28 ,  A61P43/00 ,  C12N15/63

CPC classification number: C07K16/28 ,  A61P43/00 ,  C12N15/63 ,  C07K2317/565

Abstract: The present disclosure relates to TM4SF5-specific humanized antibodies and uses thereof.

公开(公告)号：US20240254155A1

公开(公告)日：2024-08-01

申请号：US18564361

申请日：2022-05-04

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyung Won RYU ,  Su Ui LEE ,  Sei-Ryang OH ,  Jae-Won LEE ,  Doo-Young KIM ,  Hyun-Jae JANG ,  Mun-Ock KIM ,  Seong Hun JEONG

IPC: C07H15/256 ,  A61K31/704 ,  A61K36/21 ,  A61P11/06 ,  A61P29/00 ,  C07H1/08

CPC classification number: C07H15/256 ,  A61K31/704 ,  A61K36/21 ,  A61P11/06 ,  A61P29/00 ,  C07H1/08 ,  A61K2236/33 ,  A61K2236/55

Abstract: The present invention relates to a novel compound isolated from spinach, and a composition comprising same for preventing or treating inflammatory diseases, and, more particularly, to a novel medicagenic acid glycoside compound isolated from spinach, a preparation method therefor, and a composition comprising same for preventing or treating inflammatory diseases.

公开(公告)号：US20240216428A1

公开(公告)日：2024-07-04

申请号：US18288815

申请日：2022-04-27

Applicant: Korea Research Institute of Bioscience and Biotechnology

Inventor： Tae-Don KIM ,  Seona CHO ,  Sooyun LEE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/02 ,  C07K14/725 ,  C07K16/28 ,  C12N15/86

CPC classification number: A61K35/17 ,  A61K39/4613 ,  A61P35/02 ,  C07K14/7051 ,  C07K16/2896 ,  C12N15/86 ,  A61K2239/13 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2740/15043

Abstract: The present invention relates to a CD5 antibody and a chimeric antigen receptor (CAR) including the same. The chimeric antigen receptor of the present invention may be expressed in an immune cell to be utilized for an immuno-oncology therapy having reduced toxicity against a normal T cell.

公开(公告)号：US20240165207A1

公开(公告)日：2024-05-23

申请号：US18283589

申请日：2022-03-25

Applicant: YD LIFE SCIENCE CO., LTD ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Incheol RYU ,  Daeun JEONG ,  Sihyeon AN ,  Seong Heon KIM ,  Yunseon KIM ,  Kanghyun RYOO ,  Hyunseung LEE ,  Dong-Oh YOON ,  Myoungwoo LEE ,  Misun WON ,  Joo-Young IM

IPC: A61K38/44 ,  A61K38/19 ,  A61K38/20 ,  A61P35/00

CPC classification number: A61K38/44 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2046 ,  A61K38/208 ,  A61K38/2086 ,  A61P35/00 ,  C12Y106/02002

Abstract: The present invention relates to a composition for preventing or treating cancer, comprising a dual expression vector, and more specifically, to a method for effectively treating cancer by simultaneously inducing the actions of cancer metabolism drugs and cancer immunotherapy drugs by using a dual expression vector for simultaneously expressing an HIF-1α inhibitor and anticancer cytokines.

公开(公告)号：US20240008460A1

公开(公告)日：2024-01-11

申请号：US18034995

申请日：2021-10-15

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Sun Uk KIM ,  Young Ho PARK ,  Bo Woong SIM ,  Kyu Tae CHANG ,  Seung Hwan LEE ,  Bong Seok SONG ,  Pil Soo JEONG ,  Hae Jun YANG ,  Sang Rae LEE ,  Yeung Bae JIN ,  Kang Jin JEONG

IPC: A01K67/027 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC classification number: A01K67/0276 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  A01K2227/108 ,  A01K2217/075 ,  A01K2217/054 ,  A01K2267/0387 ,  C12N2310/20

Abstract: The present disclosure relates to a JAK3 gene-mutated severe combined immunodeficiency animal model and a method of constructing the same. In the JAK3 gene-mutated severe combined immunodeficiency animal model of the present disclosure, the JAK3 gene is specifically deficient, the expression of cytokines is regulated by controlling the number and activity of macrophages, and the thymus, lymphocytes, and Peyer's patches, which are observed in conventional severe combined immunodeficiency animal models, particularly mini-pigs, are completely lacking. In addition, the animal model of the present disclosure can be used as a treatment model for JAK3 SCID patients, as similar phenotypes are observed in patients with human severe combined immunodeficiency caused by a JAK3 gene mutation, and can be used for artificial blood development or xenotransplantation.

公开(公告)号：US20230364170A1

公开(公告)日：2023-11-16

申请号：US18024604

申请日：2021-08-18

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Su Ui LEE ,  Hyung Won RYU ,  Mun Ock KIM ,  Sei Ryang OH ,  Doo Young KIM ,  Hyun Jae JANG

IPC: A61K36/258 ,  A61K31/585 ,  A61K36/38 ,  A61K31/194 ,  A61P3/08 ,  A61P3/04

CPC classification number: A61K36/258 ,  A61K31/585 ,  A61K36/38 ,  A61K31/194 ,  A61P3/08 ,  A61P3/04

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating obesity or diabetes, and to a food composition and feed composition for preventing or alleviating obesity or diabetes, comprising as an active ingredient, an Acanthopanax extract, a garcinia cambogia extract, or compounds isolated therefrom. The composition has synergistic antidiabetic and antiobesity activity compared to that of using only an Acanthopanax extract, a garcinia cambogia extract, or compounds isolated therefrom. Therefore, it is possible to reduce the possibility of any side effects that may be caused by an overdose of or long-term administration of the garcinia cambogia extract and a substance isolated therefrom, and thus the composition can be very effectively utilized in the development of a therapeutic agent for diabetes or obesity.

公开(公告)号：US20230305028A1

公开(公告)日：2023-09-28

申请号：US18015189

申请日：2021-05-14

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Eun Kyung LIM ,  Soo Jin JANG ,  Seong Uk SON ,  Byung Hoon KANG ,  Tae Joon KANG ,  Kyu Sun LEE ,  Ju Yeon JUNG

IPC: G01N33/94 ,  C08L49/00 ,  C07D237/04 ,  G01N21/78

CPC classification number: G01N33/94 ,  C07D237/04 ,  C08L49/00 ,  G01N21/78 ,  G01N2800/307

Abstract: The present disclosure provides a reagent composition for detecting illicit drugs, the composition comprising: a diacetylene derivative compound represented by chemical formula 1; and at least one compound selected from among gabazine (SR-95531), an amine group-linked diacetylene derivative represented by chemical formula 2-1, and a gabazine-linked diacetylene derivative represented by chemical formula 2-2.

公开(公告)号：US20230304989A1

公开(公告)日：2023-09-28

申请号：US18191388

申请日：2023-03-28

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Seung-Wook CHI ,  Mi-Kyung Lee ,  Donghwa Lee ,  Sohee Oh

IPC: G01N33/487 ,  C12N15/113

CPC classification number: G01N33/48721 ,  C12N15/113 ,  C12N2310/531

Abstract: The disclosure relates to nanopore-based technology for screening of drugs against target RNA. According to the screening method of the disclosure, drugs targeting RNA can be efficiently screened even with a very small amount sample of picomolar concentration. The discovered drugs targeting RNA can be used in the treatment of diseases associated with RNAs.

公开(公告)号：US20230144344A1

公开(公告)日：2023-05-11

申请号：US17910894

申请日：2021-03-11

Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Hyo-soo KIM ,  Hyun-duk JANG ,  Kyung Seop AHN ,  Sei-Ryang OH ,  Ok-Kyoung KWON ,  Hyung Won RYU ,  Hang JIN ,  Sangho CHOI ,  Sang Woo LEE ,  Jin Hyub PAIK ,  Soo Yong KIM ,  Changyoung LEE ,  Yong In KIM ,  Hyewon KIM ,  Mijin PARK

IPC: A61K36/185 ,  A61K31/7048 ,  A61P9/00

CPC classification number: A61K36/185 ,  A61K31/7048 ,  A61P9/00 ,  A61K2236/333 ,  A61K2236/35

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cardiovascular and metabolic diseases, comprising an Elaeocarpus petiolatus extract, a fraction thereof, or a compound isolated therefrom, as an active ingredient; a food composition for preventing or improving cardiovascular and metabolic diseases; and a method for preventing or treating cardiovascular and metabolic diseases using the same.
The composition comprising an Elaeocarpus petiolatus extract, a fraction thereof, or a compound isolated therefrom inhibits the binding of Resistin-CAP1 to inhibit the production of tumor necrosis factor, and thereby has an activity of inhibiting inflammation of the cardiovascular system, and thus can be effectively used as a preventive or therapeutic measure for cardiovascular and metabolic diseases.