发明申请
US20100210646A1 2-MORPHOLIN-4-YL-PYRIMIDINES AS PI3K INHIBITORS
审中-公开
2-MORPHOLIN-4-YL-PYRIMININES作为PI3K抑制剂
- 专利标题： 2-MORPHOLIN-4-YL-PYRIMIDINES AS PI3K INHIBITORS
- 专利标题（中）： 2-MORPHOLIN-4-YL-PYRIMININES作为PI3K抑制剂
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申请号： US12594552申请日： 2008-04-14
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公开(公告)号： US20100210646A1公开(公告)日： 2010-08-19
- 发明人: Paul John Goldsmith , Timothy Colin Hancox , Neil Anthony Pegg , Stephen Joseph Shuttleworth , Jonathan Martin Large , Edward McDonald
- 申请人： Paul John Goldsmith , Timothy Colin Hancox , Neil Anthony Pegg , Stephen Joseph Shuttleworth , Jonathan Martin Large , Edward McDonald
- 申请人地址： CH Basel GB London
- 专利权人： F. Hoffmann-La Roche AG,The Institute of Cancer Research: Royal Cancer Hos pital
- 当前专利权人： F. Hoffmann-La Roche AG,The Institute of Cancer Research: Royal Cancer Hos pital
- 当前专利权人地址： CH Basel GB London
- 优先权： GB0707087.3 20070412
- 国际申请： PCT/GB08/01294 WO 20080414
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D413/14 ; A61P35/00 ; A61P37/00 ; A61P31/12 ; A61P29/00 ; A61P25/00 ; A61P9/00 ; A61P5/00 ; A61P3/00
摘要：
The invention provides a pyrimidine compound of formula (I): wherein R1 and R2 have any of the values defined herein; or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
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