发明申请
- 专利标题： BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
- 专利标题（中）： 用于治疗阿尔茨海默病的苯甲醚和苯甲酰胺抑制剂
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申请号： US12772711申请日： 2010-05-03
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公开(公告)号： US20100210693A1公开(公告)日： 2010-08-19
- 发明人: Philippe G. Nantermet , Hemaka Anthony Rajapakse , Harold G. Selnick
- 申请人： Philippe G. Nantermet , Hemaka Anthony Rajapakse , Harold G. Selnick
- 专利权人： Merck, Sharpe & Dohme Corp.
- 当前专利权人： Merck, Sharpe & Dohme Corp.
- 主分类号： A61K31/18
- IPC分类号： A61K31/18 ; C07C311/01 ; C07D333/24 ; C07D405/04 ; C07D207/09 ; C07D213/72 ; A61K31/381 ; A61K31/4025 ; A61K31/40 ; A61K31/44 ; A61P25/28
摘要：
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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