-
1.发明授权Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease 有权苄醚和苄氨基β-分泌酶抑制剂用于治疗阿尔茨海默病公开(公告)号：US07829597B2
公开(公告)日：2010-11-09
申请号：US10573232
申请日：2004-09-29
IPC分类号： C07C15/12 , C07C13/48 , A61K31/135
CPC分类号： C07D213/81 , C07C255/57 , C07C311/08 , C07C2601/02 , C07D207/06 , C07D207/08 , C07D213/76 , C07D295/192 , C07D333/20 , C07D405/04
摘要： The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂的式（I）化合物，其可用于治疗涉及β-分泌酶的疾病，例如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
-
2.发明授权Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease 有权苄醚和苄氨基β-分泌酶抑制剂用于治疗阿尔茨海默病公开(公告)号：US08008315B2
公开(公告)日：2011-08-30
申请号：US12772711
申请日：2010-05-03
IPC分类号： A01N43/40 , A61K43/42 , C07D295/00
CPC分类号： C07D213/81 , C07C255/57 , C07C311/08 , C07C2601/02 , C07D207/06 , C07D207/08 , C07D213/76 , C07D295/192 , C07D333/20 , C07D405/04
摘要： The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗涉及β-分泌酶的疾病如阿尔茨海默氏病的化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
-
3.发明申请BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权用于治疗阿尔茨海默病的苯甲醚和苯甲酰胺抑制剂公开(公告)号：US20100210693A1
公开(公告)日：2010-08-19
申请号：US12772711
申请日：2010-05-03
IPC分类号： A61K31/18 , C07C311/01 , C07D333/24 , C07D405/04 , C07D207/09 , C07D213/72 , A61K31/381 , A61K31/4025 , A61K31/40 , A61K31/44 , A61P25/28
CPC分类号： C07D213/81 , C07C255/57 , C07C311/08 , C07C2601/02 , C07D207/06 , C07D207/08 , C07D213/76 , C07D295/192 , C07D333/20 , C07D405/04
摘要： The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗涉及β-分泌酶的疾病如阿尔茨海默氏病的化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
-
4.发明授权Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease 失效用于治疗阿尔茨海默病的苯基羧酸β-分泌酶抑制剂公开(公告)号：US07348448B2
公开(公告)日：2008-03-25
申请号：US10562470
申请日：2004-06-25
IPC分类号： C07C313/00 , C07C255/00
CPC分类号： C07D207/08 , C07C233/66 , C07C255/57 , C07C311/08 , C07C2601/02 , C07D207/06 , C07D295/192 , C07D401/04
摘要： The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗涉及β-分泌酶的疾病如阿尔茨海默氏病的化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的用途。
-
-
-
搜索结果
4 条记录 (耗时 0.011 秒)
