发明申请
- 专利标题： TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF
- 专利标题（中）： 四氢喹啉-1-酮衍生物或其盐
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申请号： US12600894申请日： 2008-05-26
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公开(公告)号： US20100227866A1公开(公告)日： 2010-09-09
- 发明人: Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
- 申请人： Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
- 申请人地址： JP Chuo-ku, Tokyo
- 专利权人： ASTELLAS PHARMA INC.
- 当前专利权人： ASTELLAS PHARMA INC.
- 当前专利权人地址： JP Chuo-ku, Tokyo
- 优先权： JPP2007-140097 20070528
- 国际申请： PCT/JP2008/059621 WO 20080526
- 主分类号： A61K31/4725
- IPC分类号： A61K31/4725 ; C07D401/12 ; C07D401/14 ; A61K31/53 ; A61K31/506 ; A61P1/00 ; A61P35/00
摘要：
[Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
公开/授权文献
- US08486970B2 Tetrahydroisoquinolin-1-one derivative or salt thereof 公开/授权日：2013-07-16
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