发明申请
US20100239608A1 PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS
审中-公开
含有稳定化mRNA的药物组合物在其编码区域中进行翻译优化
- 专利标题： PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS
- 专利标题（中）： 含有稳定化mRNA的药物组合物在其编码区域中进行翻译优化
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申请号： US12787755申请日： 2010-05-26
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公开(公告)号： US20100239608A1公开(公告)日： 2010-09-23
- 发明人: FLORIAN VON DER MÜLBE , INGMAR HOERR , STEVE PASCOLO
- 申请人： FLORIAN VON DER MÜLBE , INGMAR HOERR , STEVE PASCOLO
- 申请人地址： DE TUBINGEN
- 专利权人： CUREVAC GMBH
- 当前专利权人： CUREVAC GMBH
- 当前专利权人地址： DE TUBINGEN
- 优先权： DE10127283.9 20010605
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C07H21/02 ; A61K31/7105 ; A61K39/12 ; A61K38/19 ; A61K39/29 ; A61K39/245 ; A61K39/145 ; A61P31/18 ; A61P31/12 ; A61P37/04 ; A61P31/14 ; A61P31/16 ; A61P31/20 ; A61P31/22
摘要：
The present invention relates to a pharmaceutical composition containing an mRNA that is stabilised by sequence modifications in the translated region and is optimised for the translation. The pharmaceutical composition according to the invention is particularly suitable as an inoculating agent as well as a therapeutic agent for tissue regeneration. In addition a process is described for determining sequence modifications that serve for the stabilisation and translation optimisation of mRNA.
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