发明申请
- 专利标题： Preparation of Saturated Ketone Morphinan Compounds by Catalytic Isomerization
- 专利标题（中）： 通过催化异构化制备饱和酮吗啡喃化合物
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申请号： US12757064申请日： 2010-04-09
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公开(公告)号： US20100261904A1公开(公告)日： 2010-10-14
- 发明人: Peter X. Wang , Tao Jiang , David W. Berberich
- 申请人： Peter X. Wang , Tao Jiang , David W. Berberich
- 申请人地址： US MO Hazelwood
- 专利权人： Mallinckrodt Inc.
- 当前专利权人： Mallinckrodt Inc.
- 当前专利权人地址： US MO Hazelwood
- 主分类号： C07D489/00
- IPC分类号： C07D489/00
摘要：
The present invention provides processes for the preparation of saturated ketone morphinan compounds by catalytic isomerization. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an allyl-transition metal catalyst.
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