发明申请
- 专利标题： DUAL-ACTING ANTIHYPERTENSIVE AGENTS
- 专利标题（中）： 双作用抗菌剂
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申请号： US12826976申请日： 2010-06-30
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公开(公告)号： US20100267788A1公开(公告)日： 2010-10-21
- 发明人: Seok-Ki CHOI , Paul R. FATHEREE , Sharath HEGDE , Ryan HUDSON , Keith JENDZA , Daniel MARQUESS , Robert M. McKINNELL , Vivek SASIKUMAR
- 申请人： Seok-Ki CHOI , Paul R. FATHEREE , Sharath HEGDE , Ryan HUDSON , Keith JENDZA , Daniel MARQUESS , Robert M. McKINNELL , Vivek SASIKUMAR
- 申请人地址： US CA South San Francisco
- 专利权人： THERAVANCE, INC.
- 当前专利权人： THERAVANCE, INC.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61P9/12 ; A61P9/04 ; A61K31/196 ; A61K31/18
摘要：
The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
公开/授权文献
- US08143298B2 Dual-acting antihypertensive agents 公开/授权日：2012-03-27
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