发明申请
- 专利标题： ANGIOTENSIN II RECEPTOR ANTAGONISTS
- 专利标题（中）： ANGIOTENSIN II受体拮抗剂
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申请号： US12743402申请日： 2008-11-21
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公开(公告)号： US20100273845A1公开(公告)日： 2010-10-28
- 发明人: Amjad Ali , Michael Man-Chu Lo , Chris Franklin , Nicoletta Almirante , Silvia Stefanini , Laura Storoni , Stefano Biondi , Ennio Ongini
- 申请人： Amjad Ali , Michael Man-Chu Lo , Chris Franklin , Nicoletta Almirante , Silvia Stefanini , Laura Storoni , Stefano Biondi , Ennio Ongini
- 国际申请： PCT/US08/12984 WO 20081121
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; C07D403/10 ; A61P9/12 ; A61K31/4178
摘要：
A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is 1) —(CH2)3R5, 2) —C(O)(CH2)2R5, 3) —C(R1R2)OC(O)O(CH2)nR5, wherein n is 1 or 2, 4) —C(R1R2)OC(O)CH2CH2R5, 5) —C(R1R2)OC(O)OCH2CH2C(R3R4)R5, provided that when Y is —C(O)(CH2)2R5, then R is R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is —CH(ONO2)CH(ONO2)R6; R6 is selected from CH3, CH2CH3 and CH(CH3)2; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
公开/授权文献
- US08252825B2 Angiotensin II receptor antagonists 公开/授权日：2012-08-28
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