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    ANGIOTENSIN II RECEPTOR ANTAGONISTS
    3.
    发明申请
    ANGIOTENSIN II RECEPTOR ANTAGONISTS 失效
    ANGIOTENSIN II受体拮抗剂

    公开(公告)号：US20100273845A1

    公开(公告)日：2010-10-28

    申请号：US12743402

    申请日：2008-11-21

    申请人： Amjad Ali ,  Michael Man-Chu Lo ,  Chris Franklin ,  Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Stefano Biondi ,  Ennio Ongini

    发明人： Amjad Ali ,  Michael Man-Chu Lo ,  Chris Franklin ,  Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Stefano Biondi ,  Ennio Ongini

    IPC分类号： A61K31/4184 ,  C07D403/10 ,  A61P9/12 ,  A61K31/4178

    CPC分类号： C07D403/10

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is 1) —(CH2)3R5, 2) —C(O)(CH2)2R5, 3) —C(R1R2)OC(O)O(CH2)nR5, wherein n is 1 or 2, 4) —C(R1R2)OC(O)CH2CH2R5, 5) —C(R1R2)OC(O)OCH2CH2C(R3R4)R5, provided that when Y is —C(O)(CH2)2R5, then R is R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is —CH(ONO2)CH(ONO2)R6; R6 is selected from CH3, CH2CH3 and CH(CH3)2; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构的化合物，其中R是血管紧张素受体拮抗剂活性基团，Y是1） - （CH 2）3 R 5，2）-C（O）（CH 2）2 R 5，3）-C（R 1 R 2）OC（O）O （CH 2）n R 5，其中n为1或2，4）-C（R 1 R 2）OC（O）CH 2 CH 2 R 5，5）-C（R 1 R 2）OC（O）OCH 2 CH 2 C（R 3 R 4） O）（CH 2）2 R 5，则R 1是R 1，R 2，R 3和R 4独立地选自氢和C 1-4烷基; R5是-CH（ONO2）CH（ONO2）R6; R 6选自CH 3，CH 2 CH 3和CH（CH 3）2; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    NITRIC OXIDE DONOR COMPOUNDS
    4.
    发明申请
    NITRIC OXIDE DONOR COMPOUNDS 有权
    硝酸氧化物化合物

    公开(公告)号：US20100249189A1

    公开(公告)日：2010-09-30

    申请号：US12744168

    申请日：2009-01-15

    申请人： Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Fabio Nicoli ,  Julio Lazaro Padron

    发明人： Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Fabio Nicoli ,  Julio Lazaro Padron

    IPC分类号： A61K31/34 ,  C07D493/04 ,  A61K31/4525 ,  A61P29/00 ,  A61P9/00 ,  A61P3/10 ,  A61P9/12 ,  A61P1/00 ,  A61P27/02 ,  A61P27/06 ,  A61P31/00 ,  A61P21/00 ,  A61P7/02 ,  A61P11/00 ,  A61P25/00 ,  A61P35/00

    CPC分类号： C07D493/04

    摘要： The invention relates to nitric oxide donors of the formula (I) and pharmaceutically acceptable salts or stereoisomers thereof: wherein A and A′ are independently selected from the group consisting of H and —(X)S—Y with the proviso that at least one of A or A′ is not H; wherein s is 0 or 1; X is selected from the group consisting of: —CO—, —COO—, —CONH— and —SO2— or Y is straight or branched C1-C20 alkyl chain, preferably C1-C10 alkyl chain, substituted with one or two —ONO2; or C1-C6 alkylenoxy-C1-C5 alkyl wherein the alkyl group is substituted by one or two —ONO2 groups. The invention also provides novel compositions comprising at least one compound of the invention and at least one therapeutic agent.

    摘要翻译： 本发明涉及式（I）的一氧化氮供体及其药学上可接受的盐或立体异构体：其中A和A'独立地选自H和 - （X）S-Y，条件是至少一个 A或A'不是H; 其中s为0或1; X选自：-CO - ， - COO - ， - CONH-和-SO 2 - ，或Y是被一个或两个-ONO 2取代的直链或支链C 1 -C 20烷基链，优选C 1 -C 10烷基链 ; 或其中烷基被一个或两个-ONO 2基团取代的C 1 -C 6亚烷基氧基-C 1 -C 5烷基。 本发明还提供包含至少一种本发明化合物和至少一种治疗剂的新型组合物。

    Angiotensin II receptor antagonists
    5.
    发明申请
    Angiotensin II receptor antagonists 有权
    血管紧张素II受体拮抗剂

    公开(公告)号：US20080194660A1

    公开(公告)日：2008-08-14

    申请号：US12000247

    申请日：2007-12-11

    申请人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    发明人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    IPC分类号： A61K31/41 ,  C07D257/04 ,  A61P9/12

    CPC分类号： C07D403/10

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5-; Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有其中R是血管紧张素受体拮抗剂活性基团的结构的化合物，Y是-Y 1 -Y 2 -Y 3 -Y 3， SUP> 4 Y 1是C（R 1 R 2）2）。 R 1选自氢和C 1-4烷基; R 2选自氢，C 1-4烷基和-OC（O）C 1-4烷基; Y 2是O或CH 2; Y 3是C（O）或CH 2 O 2; Y 4是O或CH 2; （CH 2）2 - （X）0-1 - （CH 3） 0-1 <或>不存在; X是-O-或-CR 3 R 4 - 。 和R 3和R 4独立地选自氢和C 1 -C 4烷基 ; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    Nitric oxide donor compounds
    6.
    发明授权
    Nitric oxide donor compounds 有权
    一氧化二氮供体化合物

    公开(公告)号：US08003811B2

    公开(公告)日：2011-08-23

    申请号：US12744168

    申请日：2009-01-15

    申请人： Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Fabio Nicoli ,  Julio Lazaro Padron ,  Stefano Biondi

    发明人： Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Fabio Nicoli ,  Julio Lazaro Padron ,  Stefano Biondi

    IPC分类号： C07D493/00 ,  A61K31/45

    CPC分类号： C07D493/04

    摘要： The invention relates to nitric oxide donors of the formula (I) and pharmaceutically acceptable salts or stereoisomers thereof: wherein A and A′ are independently selected from the group consisting of H and —(X)s—Y with the proviso that at least one of A or A′ is not H; wherein s is 0 or 1; X is selected from the group consisting of: —CO—, —COO—, —CONH— and —SO2— or Y is straight or branched C1-C20 alkyl chain, preferably C1-C10 alkyl chain, substituted with one or two —ONO2; or C1-C6 alkylenoxy-C1-C5 alkyl wherein the alkyl group is substituted by one or two —ONO2 groups. The invention also provides novel compositions comprising at least one compound of the invention and at least one therapeutic agent.

    摘要翻译： 本发明涉及式（I）的一氧化氮供体及其药学上可接受的盐或立体异构体：其中A和A'独立地选自H和 - （X）s-Y，条件是至少一个 A或A'不是H; 其中s为0或1; X选自：-CO - ， - COO - ， - CONH-和-SO 2 - ，或Y是被一个或两个-ONO 2取代的直链或支链C 1 -C 20烷基链，优选C 1 -C 10烷基链 ; 或其中烷基被一个或两个-ONO 2基团取代的C 1 -C 6亚烷基氧基-C 1 -C 5烷基。 本发明还提供包含至少一种本发明化合物和至少一种治疗剂的新型组合物。

    Angiotensin II receptor antagonists
    7.
    发明授权
    Angiotensin II receptor antagonists 有权
    血管紧张素II受体拮抗剂

    公开(公告)号：US07880014B2

    公开(公告)日：2011-02-01

    申请号：US12000247

    申请日：2007-12-11

    申请人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    发明人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    IPC分类号： C07D257/00 ,  C07D403/00

    CPC分类号： C07D403/10

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5-; Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构的化合物，其中R是血管紧张素受体拮抗剂活性基团，Y是-Y1-Y2-Y3-Y4-Y5-; Y1是C（R1R2）; R 1选自氢和C 1-4烷基; R 2选自氢，C 1-4烷基和-OC（O）C 1-4烷基; Y2是O或CH2; Y 3是C（O）或CH 2; Y4是O或CH2; Y 5是 - （CH 2）1-2 - （X）0-1 - （CH 2）0-1-或不存在; X是-O-或-CR 3 R 4 - ; 并且R 3和R 4独立地选自氢和C 1 -C 4烷基; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    ANGIOTENSIN II RECEPTOR ANTAGONISTS
    8.
    发明申请
    ANGIOTENSIN II RECEPTOR ANTAGONISTS 审中-公开
    ANGIOTENSIN II受体拮抗剂

    公开(公告)号：US20100152259A1

    公开(公告)日：2010-06-17

    申请号：US12516482

    申请日：2007-12-11

    申请人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    发明人： Iyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali ,  Chris Franklin ,  Nicoletta Almirante ,  Laura Storoni ,  Silvia Stefanini

    IPC分类号： C07D403/10 ,  A61K31/4184 ,  A61P9/12

    CPC分类号： C07D403/10

    摘要： A compound having the structure (Formula I), wherein R an angiotensin receptor antagonist active group, Y is Y1—Y2—Y3—Y4—Y5. Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and -0C(0)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is —(CH2)1-2—(X)0-1—CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构（式I）的化合物，其中R为血管紧张素受体拮抗剂活性基团，Y为Y1-Y2-Y3-Y4-Y5。 Y1是C（R1R2）; R 1选自氢和C 1-4烷基; R 2选自氢，C 1-4烷基和-C（O）C 1-4烷基; Y2是O或CH2; Y 3是C（O）或CH 2; Y4是O或CH2; Y 5是 - （CH 2）1-2 - （X）0-1-CH 2）0-1-或不存在; X是-O-或-CR 3 R 4 - ; 并且R 3和R 4独立地选自氢和C 1 -C 4烷基; 或其药学上可接受的盐或水合物，其可用于治疗高血压。