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    ANGIOTENSIN II RECEPTOR ANTAGONISTS
    1.
    发明申请
    ANGIOTENSIN II RECEPTOR ANTAGONISTS 失效
    ANGIOTENSIN II受体拮抗剂

    公开(公告)号：US20100273845A1

    公开(公告)日：2010-10-28

    申请号：US12743402

    申请日：2008-11-21

    申请人： Amjad Ali ,  Michael Man-Chu Lo ,  Chris Franklin ,  Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Stefano Biondi ,  Ennio Ongini

    发明人： Amjad Ali ,  Michael Man-Chu Lo ,  Chris Franklin ,  Nicoletta Almirante ,  Silvia Stefanini ,  Laura Storoni ,  Stefano Biondi ,  Ennio Ongini

    IPC分类号： A61K31/4184 ,  C07D403/10 ,  A61P9/12 ,  A61K31/4178

    CPC分类号： C07D403/10

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is 1) —(CH2)3R5, 2) —C(O)(CH2)2R5, 3) —C(R1R2)OC(O)O(CH2)nR5, wherein n is 1 or 2, 4) —C(R1R2)OC(O)CH2CH2R5, 5) —C(R1R2)OC(O)OCH2CH2C(R3R4)R5, provided that when Y is —C(O)(CH2)2R5, then R is R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is —CH(ONO2)CH(ONO2)R6; R6 is selected from CH3, CH2CH3 and CH(CH3)2; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构的化合物，其中R是血管紧张素受体拮抗剂活性基团，Y是1） - （CH 2）3 R 5，2）-C（O）（CH 2）2 R 5，3）-C（R 1 R 2）OC（O）O （CH 2）n R 5，其中n为1或2，4）-C（R 1 R 2）OC（O）CH 2 CH 2 R 5，5）-C（R 1 R 2）OC（O）OCH 2 CH 2 C（R 3 R 4） O）（CH 2）2 R 5，则R 1是R 1，R 2，R 3和R 4独立地选自氢和C 1-4烷基; R5是-CH（ONO2）CH（ONO2）R6; R 6选自CH 3，CH 2 CH 3和CH（CH 3）2; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    Angiotensin II receptor antagonists
    7.
    发明授权
    Angiotensin II receptor antagonists 失效
    血管紧张素II受体拮抗剂

    公开(公告)号：US08293777B2

    公开(公告)日：2012-10-23

    申请号：US12629419

    申请日：2009-12-02

    申请人： Michael Man-Chu Lo ,  Amjad Ali ,  Ravi P. Nargund

    发明人： Michael Man-Chu Lo ,  Amjad Ali ,  Ravi P. Nargund

    IPC分类号： A61K31/34 ,  A61K31/41 ,  C07D249/00 ,  C07D409/02

    CPC分类号： C07D403/10 ,  C07D235/08 ,  C07D257/04 ,  C07D409/06

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of —O—C1-6 alkyl, —O-aryl, —O-heteroaryl, —O—C3-8 cycloalkyl, —C1-6 alkyl, -aryl, -heteroaryl, and —C3-8 cycloalkyl; R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有其中R为血管紧张素受体拮抗剂活性基团且Y为Y的结构的化合物选自R 1选自-O-C 1-6烷基，-O-芳基，-O- 杂芳基，-O-C 3-8环烷基，-C 1-6烷基， - 芳基， - 杂芳基和-C 3-8环烷基; R2和R3独立地选自氢和C 1-4烷基，或其药学上可接受的盐或水合物，其可用于治疗高血压。

    ANGIOTENSIN II RECEPTOR ANTAGONISTS
    8.
    发明申请
    ANGIOTENSIN II RECEPTOR ANTAGONISTS 有权
    ANGIOTENSIN II受体拮抗剂

    公开(公告)号：US20100292192A1

    公开(公告)日：2010-11-18

    申请号：US12812547

    申请日：2009-01-08

    申请人： Amjad Ali ,  Michael Man-Chu Lo ,  Christopher Franklin ,  Brent R. Whitehead

    发明人： Amjad Ali ,  Michael Man-Chu Lo ,  Christopher Franklin ,  Brent R. Whitehead

    IPC分类号： A61K31/655 ,  C07C245/24 ,  A61P9/12 ,  A61P7/10

    CPC分类号： C07D403/10 ,  C07D235/20 ,  C07D257/04 ,  C07D401/14 ,  C07D409/06

    摘要： A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is selected from the group consisting of and 2) —C(R1H)OC(O)X((CR12R13)—(CHR10)m—(CH2)n—Zp—(CH2)q—(CHR11)r—(CR16R17))—R5;Z is —O— or —(CR14R15)_; m, n, p, q, and r are independently selected from the group consisting of 0 and 1; X is —O— or —(CR18R19)—; R1 is selected from the group consisting of hydrogen, C1-4 alkyl, aryl and C1-4 alkylaryl; R5 is —O—N═N(O)—NR3R4; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

    摘要翻译： 具有结构的化合物，其中R是血管紧张素受体拮抗剂活性基团，Y选自和：2）-C（R 1 H）OC（O）X（（CR 12 R 13） - （CHR 10）m - （CH 2）n -Z-（CH 2）q - （CHR 11）r - （CR 16 R 17）） - R 5; Z是-O-或 - （CR14R15）_; m，n，p，q和r独立地选自0和1组成的组; X是-O-或 - （CR 18 R 19） - ; R1选自氢，C1-4烷基，芳基和C1-4烷基芳基; R5是-O-N = N（O）-NR3R4; 或其药学上可接受的盐或水合物，其可用于治疗高血压。

    Diazeniumdiolate cyclohexyl derivatives
    9.
    发明授权
    Diazeniumdiolate cyclohexyl derivatives 有权
    二氮烯二硫代环己基衍生物

    公开(公告)号：US09272987B2

    公开(公告)日：2016-03-01

    申请号：US14115139

    申请日：2012-04-27

    申请人： Amjad Ali ,  Michael Man-Chu Lo ,  Lin Yan

    发明人： Amjad Ali ,  Michael Man-Chu Lo ,  Lin Yan

    IPC分类号： C07C245/24 ,  C07C247/06 ,  C07D231/12 ,  C07D249/04 ,  C07D317/72 ,  C07C291/08

    CPC分类号： C07C247/06 ,  C07B2200/07 ,  C07C245/24 ,  C07C291/08 ,  C07C2601/14 ,  C07D231/12 ,  C07D249/04 ,  C07D317/72

    摘要： A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R6 is hydrogen, —OH, —C1-6alkyl, —OC1-6alkyl, aryl, or halogen, or together with R7, forms an oxo group, or together with R7 and the atom to which they are attached, form a 5-7-membered carbocycle ring or a 5-7-membered heterocyclic ring having 1, 2, or 3 heteroatoms, wherein alkyl and aryl are unsubstituted or independently mono-, di-, or tri-substituted with R14; R7 is hydrogen, C1-6alkyl, —CF3, aryl, —O-aryl, —O—C1-6alkyl, —C(O)OC1-6alkyl, —C(R15R16)OH, a 5-7-membered heteroaryl having 1, 2, 3 or 4 nitrogen atoms, or halogen, or together with R6, forms an oxo group, or together with R6 and the atom to which they are attached, form a 5-7-membered carbocycle ring or a 5-7-membered heterocyclic ring having 1, 2, or 3 heteroatoms wherein alkyl, aryl and heteroaryl are unsubstituted or independently mono-, di- or tri-substituted with R14; R12 is hydrogen, C1-6alkyl, or —(CH2)1-2OH, or together with R13 and the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or independently mono-, di- or tri-substituted with halogen or —C1-6alkyl; R13 is —C1-6alkyl or —(CH2)1-2OH, or together with R12 and the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or independently mono-, di- or tri-substituted with halogen or —C1-6alkyl.

    摘要翻译： 具有结构或其药学上可接受的盐的化合物，其中R 6是氢，-OH，-C 1-6烷基，-OC 1-6烷基，芳基或卤素，或与R 7一起形成氧代基，或与R 7和 它们连接的原子形成5-7元碳环或具有1,2或3个杂原子的5-7元杂环，其中烷基和芳基是未取代的或独立地是单 - ，二 - 或 用R14三取代; R 7是氢，C 1-6烷基，-CF 3，芳基，-O-芳基，-O-C 1-6烷基，-C（O）OC 1-6烷基，-C（R 15 R 16）OH，5- ，2,3或4个氮原子，或卤素，或与R6一起形成氧代基团，或与R6及其连接的原子一起形成5-7元碳环或5-7元碳环， 其中烷基，芳基和杂芳基是未取代的或独立地被R 14取代或被二取代或三取代的杂环基; R 12是氢，C 1-6烷基或 - （CH 2）1-2 OH，或者与R 13和它们所连接的氮原子一起形成含有一个氮原子和0或1个氧的4-至7-元杂环 原子，其中所述环是未取代的或独立地被卤素或-C 1-6烷基单，二或三取代; R 13是-C 1-6烷基或 - （CH 2）1-2 OH，或与R 12和它们所连接的氮原子一起形成含有一个氮原子和0或1个氧原子的4-至7-元杂环， 其中所述环是未取代的或独立地被卤素或-C 1-6烷基单，二或三取代。