发明申请
US20100278839A1 ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY
有权
抗生素稳定性增强的神经生长因子（NGF）抗体
- 专利标题： ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY
- 专利标题（中）： 抗生素稳定性增强的神经生长因子（NGF）抗体
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申请号： US12773488申请日： 2010-05-04
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公开(公告)号： US20100278839A1公开(公告)日： 2010-11-04
- 发明人: John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
- 申请人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
- 申请人地址： NL Utrecht
- 专利权人： PANGENETICS 110 BV
- 当前专利权人： PANGENETICS 110 BV
- 当前专利权人地址： NL Utrecht
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; C12N15/63 ; C12N5/10 ; A61P25/00
摘要：
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
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