摘要:
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
摘要:
A cargo restraining device suitable for restraining barrel-shaped containers or drums is disclosed, which includes a platform, which is spaced from the underlying supporting surface or floor, by horizontal supporting members which extend the length of at least the flat portion of the platform, so as to provide a raised deck for the containers. At one end of the platform, an upright or vertical frame is connected to the supporting members, to prevent the containers from falling off the platform. The other end of the platform can be rounded over to define a snub-nose; or alternatively the other ends of the horizontal supporting members can project beyond the platform (which is otherwise flat) and be rounded into snub-nosed portions. In consequence, should the drums shift or move, whereby damage might ordinarily occur, the chimes or rims of the drums tend to flow around the snub-nose (or snub-noses if defined at the supporting members) without any significant damage. Thus, the containers, instead of falling off when moved, gently slide about and off the snub-nosed portion or portions; and no abrupt discontinuous edges are encountered. At both ends of the horizontal support members, floor piercing members are provided, which are normally oriented to the floor piercing position, and firmly hold the platform in place. A strap may be placed around the containers, and secured at the ends to an upright frame, to further restrain movement of the drums on the platform.
摘要:
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.