发明申请
- 专利标题: OLIGOCARBONATE MOLECULAR TRANSPORTERS
- 专利标题(中): 低分子量分子运输机
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申请号: US12433693申请日: 2009-04-30
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公开(公告)号: US20100280219A1公开(公告)日: 2010-11-04
- 发明人: Christina Cooley , James L. Hedrick , Matthew Kiesewetter , Fredrik Nederberg , Brian Trantow , Robert Waymouth , Paul Wender
- 申请人: Christina Cooley , James L. Hedrick , Matthew Kiesewetter , Fredrik Nederberg , Brian Trantow , Robert Waymouth , Paul Wender
- 专利权人: International Business Machines Corporation,Stanford University
- 当前专利权人: International Business Machines Corporation,Stanford University
- 主分类号: C08G64/02
- IPC分类号: C08G64/02 ; C07D323/04 ; C08G64/30
摘要:
A cyclic carbonate monomer, including: wherein R1, R2, and R3 are independently selected from the group consisting of H, linear or branched, substituted or unsubstituted alkyl; R10 is a connecting group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; R4 is an optional bridging group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; Z is selected from the group consisting of O, NH, NR, and S; G is a guanidine group; and P is a protecting group.The cylic carbonate monomer can be reacted with an initiator including a drug, drug candidate, probe or other molecule of interest to form an oligomer with the molecule of interest attached to one end of a carbonate backbone and guanidine groups attached to the carbonate backbone.
公开/授权文献
- US07939621B2 Oligocarbonate molecular transporters 公开/授权日:2011-05-10
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