公开(公告)号：US20100280219A1

公开(公告)日：2010-11-04

申请号：US12433693

申请日：2009-04-30

申请人： Christina Cooley ,  James L. Hedrick ,  Matthew Kiesewetter ,  Fredrik Nederberg ,  Brian Trantow ,  Robert Waymouth ,  Paul Wender

发明人： Christina Cooley ,  James L. Hedrick ,  Matthew Kiesewetter ,  Fredrik Nederberg ,  Brian Trantow ,  Robert Waymouth ,  Paul Wender

IPC分类号： C08G64/02 ,  C07D323/04 ,  C08G64/30

CPC分类号： C07D319/06 ,  A61K47/55 ,  C08G64/0225 ,  C08G64/30 ,  Y02P20/55

摘要： A cyclic carbonate monomer, including: wherein R1, R2, and R3 are independently selected from the group consisting of H, linear or branched, substituted or unsubstituted alkyl; R10 is a connecting group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; R4 is an optional bridging group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; Z is selected from the group consisting of O, NH, NR, and S; G is a guanidine group; and P is a protecting group.The cylic carbonate monomer can be reacted with an initiator including a drug, drug candidate, probe or other molecule of interest to form an oligomer with the molecule of interest attached to one end of a carbonate backbone and guanidine groups attached to the carbonate backbone.

摘要翻译： 一种环状碳酸酯单体，包括：其中R1，R2和R3独立地选自H，直链或支链，取代或未取代的烷基; R10是选自直链或支链，取代或未取代的烷基，杂烷基，环烷基，杂环，芳基和杂芳基的连接基团; R4是选自直链或支链，取代或未取代的烷基，杂烷基，环烷基，杂环，芳基和杂芳基的任选的桥连基团; Z选自O，NH，NR和S; G是胍基; 而P是保护基。 环状碳酸酯单体可以与包括药物，候选药物，探针或其他目标分子的引发剂反应，以形成与目标分子连接在碳酸酯骨架的一端和与碳酸酯骨架连接的胍基的低聚物。

公开(公告)号：US07939621B2

公开(公告)日：2011-05-10

申请号：US12433693

申请日：2009-04-30

申请人： Christina Cooley ,  James Lupton Hedrick ,  Matthew Kiesewetter ,  Fredrik Nederberg ,  Brian Trantow ,  Robert Waymouth ,  Paul Wender

发明人： Christina Cooley ,  James Lupton Hedrick ,  Matthew Kiesewetter ,  Fredrik Nederberg ,  Brian Trantow ,  Robert Waymouth ,  Paul Wender

IPC分类号： C08G64/00 ,  C08G63/02

CPC分类号： C07D319/06 ,  A61K47/55 ,  C08G64/0225 ,  C08G64/30 ,  Y02P20/55

摘要： A cyclic carbonate monomer, including: wherein R1, R2, and R3 are independently selected from the group consisting of H, linear or branched, substituted or unsubstituted alkyl; R10 is a connecting group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; R4 is an optional bridging group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; Z is selected from the group consisting of O, NH, NR, and S; G is a guanidine group; and P is a protecting group. The cylic carbonate monomer can be reacted with an initiator including a drug, drug candidate, probe or other molecule of interest to form an oligomer with the molecule of interest attached to one end of a carbonate backbone and guanidine groups attached to the carbonate backbone.

摘要翻译： 一种环状碳酸酯单体，包括：其中R1，R2和R3独立地选自H，直链或支链，取代或未取代的烷基; R10是选自直链或支链，取代或未取代的烷基，杂烷基，环烷基，杂环，芳基和杂芳基的连接基团; R4是选自直链或支链，取代或未取代的烷基，杂烷基，环烷基，杂环，芳基和杂芳基的任选的桥连基团; Z选自O，NH，NR和S; G是胍基; 而P是保护基。 环状碳酸酯单体可以与包括药物，候选药物，探针或其他目标分子的引发剂反应，以形成与目标分子连接在碳酸酯骨架的一端和与碳酸酯骨架连接的胍基的低聚物。