发明申请
US20100280251A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
有权
制备2-氨基-5-氰基苯甲酸衍生物的方法
- 专利标题： PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
- 专利标题（中）： 制备2-氨基-5-氰基苯甲酸衍生物的方法
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申请号： US12516807申请日： 2007-12-18
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公开(公告)号： US20100280251A1公开(公告)日： 2010-11-04
- 发明人: Joerg Bruening , Gary David Annis , Martin James Currie , Donald J. Dumas , Rafael Shapiro
- 申请人： Joerg Bruening , Gary David Annis , Martin James Currie , Donald J. Dumas , Rafael Shapiro
- 申请人地址： US DE Wilmington
- 专利权人： E.I. Du Pont De Nemours and Company
- 当前专利权人： E.I. Du Pont De Nemours and Company
- 当前专利权人地址： US DE Wilmington
- 国际申请： PCT/US07/25800 WO 20071218
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07C253/32 ; C07C231/22 ; C07D231/22 ; C07D231/12
摘要：
Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; Y is Br or Cl; X is NR13 or O; n is 0 or 1; and R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure.Also disclosed is a method for preparing a compound of Formula 2 wherein Y is Br and R1 is NHR3 comprising introducing a gas containing bromine into a liquid containing a compound of Formula 4, and further disclosed is a method for preparing a compound of Formula 5 wherein R14, R15, R16 and Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above.