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    PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
    1.
    发明申请
    PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES 有权
    制备2-氨基-5-氰基苯甲酸衍生物的方法

    公开(公告)号：US20100280251A1

    公开(公告)日：2010-11-04

    申请号：US12516807

    申请日：2007-12-18

    申请人： Joerg Bruening ,  Gary David Annis ,  Martin James Currie ,  Donald J. Dumas ,  Rafael Shapiro

    发明人： Joerg Bruening ,  Gary David Annis ,  Martin James Currie ,  Donald J. Dumas ,  Rafael Shapiro

    IPC分类号： C07D401/04 ,  C07C253/32 ,  C07C231/22 ,  C07D231/22 ,  C07D231/12

    CPC分类号： C07C253/14 ,  C07C231/12 ,  C07C233/65 ,  C07C255/58

    摘要： Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; Y is Br or Cl; X is NR13 or O; n is 0 or 1; and R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure.Also disclosed is a method for preparing a compound of Formula 2 wherein Y is Br and R1 is NHR3 comprising introducing a gas containing bromine into a liquid containing a compound of Formula 4, and further disclosed is a method for preparing a compound of Formula 5 wherein R14, R15, R16 and Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above.

    摘要翻译： 公开了一种制备式1化合物的方法，包括使式2化合物与金属氰化物试剂，铜（I）盐试剂，碘化物盐试剂和至少一种式3化合物（其中R1是NHR3或OR4）接触 ; R2是CH3或Cl; R3是H，C1-C4烷基，环丙基，环丙基环丙基，环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; Y为Br或Cl; X为NR 13或O; n为0或1; 并且R5，R6，R7，R8，R9，R10，R11，R12和R13如本公开所定义。 还公开了制备式2化合物的方法，其中Y是Br，R 1是NHR 3，包括将含溴的气体引入含有式4化合物的液体中，并且还公开了制备式5化合物的方法，其中 R14，R15，R16和Z如本公开中所定义，使用式1的化合物，其特征在于通过上述方法制备式1的化合物。

    Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-0X0-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naph-thalenecarboxamide
    2.
    发明授权
    Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-0X0-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naph-thalenecarboxamide 有权
    结晶形式的4- [5- [3-氯-5-（三氟甲基）苯基] -4,5-二氢-5-（三氟甲基）-3-异恶唑基] -N- [2-0X0-2 - [（2 ，2,2-三氟乙基）氨基]乙基] -1-萘-2-甲酸甲酯

    公开(公告)号：US08598087B2

    公开(公告)日：2013-12-03

    申请号：US13700222

    申请日：2011-05-19

    申请人： Martin James Currie

    发明人： Martin James Currie

    IPC分类号： A01N43/80 ,  C07D261/02

    CPC分类号： C07D261/04 ,  A01N43/80 ,  A61K31/42 ,  A01N25/12

    摘要： Disclosed is a solid form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide (Compound 1). Also disclosed are compositions containing a solid form of Compound 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a solid form of Compound 1 or a composition containing a solid form of Compound 1.

    摘要翻译： 公开了固体形式的4- [5- [3-氯-5-（三氟甲基）苯基] -4,5-二氢-5-（三氟甲基）-3-异恶唑基] -N- [2-氧代-2- [（2,2,2-三氟乙基）氨基]乙基] -1-萘甲酰胺（化合物1）。 还公开了含有固体形式的化合物1和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的固体形式的化合物1或含有固体形式的化合物1的组合物接触。