发明申请
US20100291134A1 TRUNCATED HEPATITIS C VIRUS NS5 DOMAIN AND FUSION PROTEINS COMPRISING SAME
审中-公开
截断性HEPATITIS C病毒NS5域和包含其的融合蛋白
- 专利标题： TRUNCATED HEPATITIS C VIRUS NS5 DOMAIN AND FUSION PROTEINS COMPRISING SAME
- 专利标题（中）： 截断性HEPATITIS C病毒NS5域和包含其的融合蛋白
-
申请号： US12847312申请日： 2010-07-30
-
公开(公告)号： US20100291134A1公开(公告)日： 2010-11-18
- 发明人: Michael Houghton , Angelica Medina-Selby , Doris Coit
- 申请人： Michael Houghton , Angelica Medina-Selby , Doris Coit
- 专利权人： Chiron Corporation
- 当前专利权人： Chiron Corporation
- 主分类号： A61K39/29
- IPC分类号： A61K39/29 ; C07K2/00 ; C07K14/00 ; A61K38/00 ; C07H21/04 ; C12N15/79 ; C12N5/10 ; C12P21/00 ; A61P37/04 ; A61P31/14
摘要：
The invention provides truncated HCV NS5 polypeptides and fusion proteins comprising the truncated NS5 polypeptides, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating an immune response to HCV, for example a cellular immune response to HCV, such as activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.
信息查询
