发明申请
- 专利标题： TREATMENT OF PROTEIN FOLDING DISORDERS
- 专利标题（中）： 蛋白质折叠病的治疗
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申请号： US12744029申请日： 2008-11-20
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公开(公告)号： US20100317690A1公开(公告)日： 2010-12-16
- 发明人: Akane Kawamura , Alan Geoffrey Roach , Francis Xavier Wilson , Jonathon Mark Tinsley , Robert Nash , Richard Storer
- 申请人： Akane Kawamura , Alan Geoffrey Roach , Francis Xavier Wilson , Jonathon Mark Tinsley , Robert Nash , Richard Storer
- 专利权人： SUMMIT CORPORATION PLC
- 当前专利权人： SUMMIT CORPORATION PLC
- 优先权： GB0722792.9 20071121; GB0722793.7 20071121; GB0722794.5 20071121
- 国际申请： PCT/GB08/03885 WO 20081120
- 主分类号： A61K31/46
- IPC分类号： A61K31/46 ; A61K31/403 ; A61K31/4015 ; A61K31/435 ; A61K31/445 ; C07D487/02 ; C07D207/12 ; C07D207/24 ; C07D451/06 ; C07D455/02 ; C07D211/40 ; A61P43/00 ; A61P3/00
摘要：
Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular, polyhydroxylated alkaloids and imino sugars which are pharmacoperones of an enzyme and which do not bind to a catalytic site of said enzyme are described.
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