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    TREATMENT OF ENERGY UTILIZATION DISEASE
    1.
    发明申请
    TREATMENT OF ENERGY UTILIZATION DISEASE 审中-公开
    治疗能源利用疾病

    公开(公告)号：US20140011841A1

    公开(公告)日：2014-01-09

    申请号：US13759173

    申请日：2013-02-05

    申请人： Robert James NASH ,  Francis Xavier WILSON ,  Graeme HORNE

    发明人： Robert James NASH ,  Francis Xavier WILSON ,  Graeme HORNE

    IPC分类号： A61K31/445 ,  A61K45/06

    CPC分类号： A61K31/445 ,  A61K31/40 ,  A61K36/19 ,  A61K36/27 ,  A61K36/28 ,  A61K36/42 ,  A61K36/48 ,  A61K36/752 ,  A61K36/815 ,  A61K45/06

    摘要： Described are compositions comprising imino sugar acids for the treatment of energy utilization disease (e.g. metabolic syndrome, including any disease or disorder associated therewith, for example central obesity, elevated levels of triglycerides and diabetes, including type 1 diabetes, type 2 diabetes and insulin resistance), processes for producing said compositions from various plant sources, together with various products, compounds, compositions, medical uses and methods based thereon.

    摘要翻译： 描述了包含用于治疗能量利用疾病（例如，代谢综合征，包括与其相关的任何疾病或病症，例如中枢性肥胖，升高的甘油三酯和糖尿病水平，包括1型糖尿病，2型糖尿病和胰岛素抵抗）的亚氨基糖酸的组合物 ），从各种植物来源生产所述组合物的方法，以及基于其的各种产品，化合物，组合物，医疗用途和方法。

    Amino acid derivatives
    2.
    发明授权
    Amino acid derivatives 失效
    氨基酸衍生物

    公开(公告)号：US06018020A

    公开(公告)日：2000-01-25

    申请号：US96570

    申请日：1998-06-12

    申请人： Michael Richard Attwood ,  David Nigel Hurst ,  Philip Stephen Jones ,  Paul Brittain Kay ,  Tony Michael Raynham ,  Francis Xavier Wilson

    发明人： Michael Richard Attwood ,  David Nigel Hurst ,  Philip Stephen Jones ,  Paul Brittain Kay ,  Tony Michael Raynham ,  Francis Xavier Wilson

    IPC分类号： C12N15/09 ,  A01N43/34 ,  A01N43/36 ,  A61K38/00 ,  A61P31/12 ,  A61P31/14 ,  C07C205/04 ,  C07C205/45 ,  C07C271/18 ,  C07D207/12 ,  C07D207/20 ,  C07D211/70 ,  C07D223/04 ,  C07D227/04 ,  C07D405/10 ,  C07D407/10 ,  C07D409/10 ,  C07K7/06 ,  A61K38/08

    CPC分类号： C07K7/06 ,  A61K38/00

    摘要： The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ;R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl;R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; andR.sup.3 represents hydrogen or lower alkyl; orR.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy;R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl;R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl;R.sup.6 represents hydrogen or lower alkyl;R.sup.7 represent lower alkyl (optionally substituted by hydroxy, carboxy, aryl or lower cycloalkyl) or lower cycloalkyl;R.sup.8 represents lower alkyl optionally substituted by hydroxy, carboxy or aryl; andR.sup.9 represents lower alkylcarbonyl, carboxy-lower alkylcarbonyl, arylcarbonyl, lower alkylsulphonyl, arylsulphonyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl,and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.

    摘要翻译： 本发明提供下式的氨基酸衍生物，其中E代表CHO或B（OH）2; R 1表示低级烷基（任选被卤素，氰基，低级烷硫基，芳基 - 低级烷硫基，芳基或杂芳基取代），低级烯基或低级炔基; R 2表示任选被羟基，羧基，芳基，氨基羰基或低级环烷基取代的低级烷基; 并且R 3表示氢或低级烷基; 或R 2和R 3一起表示任选被羟基取代的二 - 或三亚甲基; R4代表低级烷基（任选被羟基，低级环烷基，羧基，芳基，低级烷硫基，氰基 - 低级烷硫基或芳基 - 低级烷硫基取代），低级烯基，芳基或低级环烷基; R5代表低级烷基（任选被羟基，低级烷硫基，芳基，芳基 - 低级烷硫基或氰基 - 低级烷硫基取代）或低级环烷基; R6代表氢或低级烷基; R7代表低级烷基（任选被羟基，羧基，芳基或低级环烷基取代）或低级环烷基; R8代表任选被羟基，羧基或芳基取代的低级烷基; 并且R 9表示低级烷基羰基，羧基 - 低级烷基羰基，芳基羰基，低级烷基磺酰基，芳基磺酰基，低级烷氧基羰基或芳基 - 低级烷氧基羰基，以及式I酸性化合物与碱的碱，其为用作抗病毒剂的病毒蛋白酶抑制剂， 治疗或预防丙型肝炎，丙型肝炎和人类GB病毒引起的感染。