Invention Application
- Patent Title: Renin Inhibitors
- Patent Title (中): 肾素抑制剂
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Application No.: US12665217Application Date: 2008-06-20
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Publication No.: US20100317697A1Publication Date: 2010-12-16
- Inventor: John J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Qing Lu , Gerard McGeehan , Beth A. Knapp-Reid , Simon Semus , Robert D. Simpson , Suresh B. Singh , Lamont R. Terrell , Colin Tice , Tritin Tran , Zherong Xu , Jing Yuan , Wei Zhao , Yongdong Y. Zhao
- Applicant: John J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Qing Lu , Gerard McGeehan , Beth A. Knapp-Reid , Simon Semus , Robert D. Simpson , Suresh B. Singh , Lamont R. Terrell , Colin Tice , Tritin Tran , Zherong Xu , Jing Yuan , Wei Zhao , Yongdong Y. Zhao
- International Application: PCT/US08/67650 WO 20080620
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D211/06
Abstract:
Disclosed are compounds having the formula (I): wherein the R1, R2, R3, X, Y, A, L, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
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