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发明申请
US20100322948A1 Bone morphogenetic protein (BMP)-binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and use of same 审中-公开
排斥指导分子（RGM）蛋白家族的蛋白质的骨形态发生蛋白（BMP）结合结构域及其功能片段及其使用

Bone morphogenetic protein (BMP)-binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and use of same
摘要：
The present invention relates to the identification and use of bone morphogenetic protein (BMP)-binding domains of members of the repulsive guidance molecule (RGM) protein family, and polypeptide fragments and fusion proteins derived therefrom. The domains, i.e., peptide fragments and fusion proteins, according to the invention are suitable as agents for the active or passive immunization of individuals, or as diagnostic and therapeutic agents for use for diseases or medical conditions in whose origin or progression a member of the RGM family and a cellular receptor associated with this molecule, such as neogenin and/or BMP in particular, is involved. The invention further relates to monoclonal and polyclonal antibodies directed against the binding domains according to the invention, and against the polypeptides derived therefrom, and to methods for producing the polypeptides, fusion proteins, and antibodies according to the invention.
摘要（中）：

本发明涉及排斥性指导分子（RGM）蛋白家族的成员的骨形态发生蛋白（BMP）结合结构域的鉴定和应用，以及从其衍生的多肽片段和融合蛋白质。 根据本发明的结构域，即肽片段和融合蛋白，适合作为个体的主动或被动免疫的试剂，或作为用于疾病或医学病症的诊断和治疗剂，其来源或进展是 涉及RGM家族和与该分子相关的细胞受体，例如特别是新生蛋白和/或BMP。 本发明还涉及针对根据本发明的结合结构域和针对本发明的多肽的单克隆抗体和多克隆抗体，以及根据本发明的用于产生多肽，融合蛋白和抗体的方法。

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