摘要:
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要:
A heat exchanger for converting thermal energy of a fluid, e.g., exhaust gas of an internal combustion engine, into electrical power, has a flow channel for conveying a hot fluid, and at least one thermoelectric module for generating electrical power is thermally connected to the flow channel. The flow channel is manufactured from a ceramic material. Thermal expansion effects of the flow channel is reduced by the ceramic material of the flow channel so that the design complexity for converting thermal energy into electrical power is reduced.
摘要:
A quenching device is described that includes at least one chamber that can be filled with quenching gas and that has a blower wheel for circulating quenching gas, in particular a quenching chamber and/or a flow channel, a drive motor, situated outside the chamber, for driving the blower being allocated to the blower wheel. The drive motor is coupled to the blower wheel so as to transmit torque via a coupling that operates in contactless fashion. Also described is a related quenching method.
摘要:
A pressure vessel for storing fuel cell reactants is disclosed. The pressure vessel includes an inner shell formed from a moldable material and forming a cavity therein, and an outer shell formed about the inner shell. A heat transfer member is disposed within the vessel cavity. The heat transfer member is thermally coupled a suitable external thermal mass external the pressure vessel to minimize the effect of thermal energy on the vessel. The heat transfer member may be a metallic structure within the cavity, or may be integrated within the inner shell on an inner shell surface. The external thermal mass may further be thermally coupled to either an active or a passive external thermal handling system for controlling the temperature of the fluid within the vessel.
摘要:
The present invention relates to the identification and use of bone morphogenetic protein (BMP)-binding domains of members of the repulsive guidance molecule (RGM) protein family, and polypeptide fragments and fusion proteins derived therefrom. The domains, i.e., peptide fragments and fusion proteins, according to the invention are suitable as agents for the active or passive immunization of individuals, or as diagnostic and therapeutic agents for use for diseases or medical conditions in whose origin or progression a member of the RGM family and a cellular receptor associated with this molecule, such as neogenin and/or BMP in particular, is involved. The invention further relates to monoclonal and polyclonal antibodies directed against the binding domains according to the invention, and against the polypeptides derived therefrom, and to methods for producing the polypeptides, fusion proteins, and antibodies according to the invention.
摘要:
An installation for the dry transformation of a material microstructure of semi-finished products, especially for dry bainitization, includes a quenching chamber and a microstructure transformation chamber situated downstream from it in the processing flow, in each case the inner space of the two chambers having applied to it excess gas pressure, at least during the respective method step, for the transformation of the material microstructure. Device(s) are provided for maintaining a minimum excess gas pressure acting on the semi-finished product, during the moving of the semi-finished product from the quenching chamber into the microstructure transformation chamber.
摘要:
The invention relates to a fit peanut fitting for containers of heat exchangers and provided for connecting the containers to a connection tube for feeding or draining a heat-transmitting, passing medium. The fit peanut fitting includes a main piece and an accompanying insert portion, whereby the main piece on one end contains a seating portion for receiving the connection tube and on the opposite end includes a stop surface being conformal with the container's outer wall surface. A passage channel passes from the seating portion to the insert portion and provides for the passing medium, whereby the insert portion projects beyond the stop surface such that at least a fixing connection to the wall opening of the container is achievable.
摘要:
This invention relates to drug screening using mammalian repulsive guidance molecules and mammalian Neogenin. In addition, the invention provides for methods of preventing, alleviating or treating various disorders of the nervous system, angiogenic disorders or disorders of the cardio-vascular system and malignancies of different etiology by disrupting the interaction between RGM and Neogenin.
摘要:
This invention relates to drug screening using mammalian repulsive guidance molecules and mammalian Neogenin. In addition, the invention provides for methods of preventing, alleviating or treating various disorders of the nervous system, angiogenic disorders or disorders of the cardio-vascular system and malignancies of different etiology by disrupting the interaction between RGM and Neogenin.
摘要:
The invention relates to a method of calibration of the beam position of a corpuscular beam. A calibration body with structures is used, wherein the structures have a structure period Ps in the plain section and within each structure there is a position L intended for the measurement. For the calibration, at least one detection signal each at structures in the plain section of the calibration body is generated, wherein the corpuscular beam is deflected with deflectors on beam target positions L1 with the beam target period P1, which is larger than half of the structure period Ps, whereby a basic calibration is used for the control of the deflectors, and wherein the beam target deflections intentionally deviate either in the beam target period P1 from the structure period Ps and/or in the beam target position L1 from the position L.