发明申请
US20100324036A1 SUBSTITUTED IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR ANTAGONISTS
审中-公开
作为MELANOCORTIN-4受体拮抗剂的取代的咪唑吡啶衍生物
- 专利标题： SUBSTITUTED IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR ANTAGONISTS
- 专利标题（中）： 作为MELANOCORTIN-4受体拮抗剂的取代的咪唑吡啶衍生物
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申请号： US12809824申请日： 2008-12-18
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公开(公告)号： US20100324036A1公开(公告)日： 2010-12-23
- 发明人: Michael Soeberdt , Philipp Weyermann , Herve Siendt , Sonja Nordhoff , Achim Feurer , Miroslav Terinek
- 申请人： Michael Soeberdt , Philipp Weyermann , Herve Siendt , Sonja Nordhoff , Achim Feurer , Miroslav Terinek
- 申请人地址： CH LIESTAL
- 专利权人： SANTHERA PHARMACEUTICALS (SCHWEIZ) AG
- 当前专利权人： SANTHERA PHARMACEUTICALS (SCHWEIZ) AG
- 当前专利权人地址： CH LIESTAL
- 优先权： EP07025029.5 20071221
- 国际申请： PCT/EP2008/010849 WO 20081218
- 主分类号： A61K31/5383
- IPC分类号： A61K31/5383 ; C07D471/04 ; A61K31/437 ; C07D498/04 ; A61P9/00 ; A61P21/00 ; A61P25/00 ; A61P25/22 ; A61P25/24 ; A61P13/12 ; A61P35/00 ; A61P29/00
摘要：
The present invention relates to substituted imidazopyridine derivatives as melanocortin-4 receptor (MC-4R) modulators, in particular as melanocortin 4 receptor antagonists. The antagonists are useful for the treatment of disorders and diseases such as cachexia induced by e.g. cancer, chronic kidney disease (CKD) or chronic heart failure (CHF), muscle wasting, anorexia induced by e.g. chemotherapy or radiotherapy, anorexia nervosa, amyotrophic lateral sclerosis (ALS), pain, neuropathic pain, anxiety and depression.
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