发明申请
- 专利标题： Method of Producing a Mouse Suitable for Engraftment, Differentiation and Proliferation of Heterologous Cells, Mouse Produced by This Method and Use of the Mouse
- 专利标题（中）： 生产适合于异源细胞的移植，分化和增殖的小鼠的方法，通过该方法产生的小鼠和使用小鼠
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申请号： US12620469申请日： 2009-11-17
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公开(公告)号： US20110010781A1公开(公告)日： 2011-01-13
- 发明人: Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- 申请人： Mamoru Ito , Kimio Kobayashi , Tatsutoshi Nakahata , Koichiro Tsuji , Sonoko Habu , Yoshio Koyanagi , Naoki Yamamoto , Kazuo Sugamura , Kiyoshi Ando , Tatsuji Nomura
- 优先权： JP367296/2000 20001201
- 主分类号： C12P21/00
- IPC分类号： C12P21/00
摘要：
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
公开/授权文献
- US08541033B2 Production of human antibodies using NOD/SCID/γcnull mice 公开/授权日：2013-09-24
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