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21 条记录 (耗时 0.041 秒)

    Method of constructing spinal injury model monkey and utilization thereof
    6.
    发明授权
    Method of constructing spinal injury model monkey and utilization thereof 有权
    构建脊髓损伤模型猴的方法及其应用

    公开(公告)号：US07753054B2

    公开(公告)日：2010-07-13

    申请号：US10496993

    申请日：2002-11-26

    申请人： Hideyuki Okano ,  Yoshiaki Toyama ,  Masaya Nakamura ,  Tatsuji Nomura ,  Yoshikuni Tanioka ,  Kiyoshi Ando ,  Yonehiro Kanemura

    发明人： Hideyuki Okano ,  Yoshiaki Toyama ,  Masaya Nakamura ,  Tatsuji Nomura ,  Yoshikuni Tanioka ,  Kiyoshi Ando ,  Yonehiro Kanemura

    IPC分类号： A61B19/00

    CPC分类号： A01K67/027 ,  A01K2227/106 ,  A01K2267/03 ,  A01K2267/0356

    摘要： A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.

    摘要翻译： 一种创建脊髓损伤猴模型的方法，其包括暴露猴子的颈椎硬脑膜并在硬脑膜上施加负荷; 由此造成的脊髓损伤猴模型; 以及使用该模型评价脊髓损伤治疗药物的方法。 根据本发明，可以产生靠近人类的猴，因此可用作人脊髓损伤的模型。 该模型能够适当评估各种药物对脊髓损伤的治疗效果。 通过使用该模型，人类神经干细胞的移植治疗首次对脊髓损伤有效。

    Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof
    9.
    发明申请
    Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof 审中-公开
    椎间盘髓核干细胞/祖细胞，培养方法及其用途

    公开(公告)号：US20130078222A1

    公开(公告)日：2013-03-28

    申请号：US13637470

    申请日：2011-03-29

    申请人： Daisuke Sakai ,  Joji Mochida ,  Kiyoshi Ando ,  Yoshihiko Nakamura

    发明人： Daisuke Sakai ,  Joji Mochida ,  Kiyoshi Ando ,  Yoshihiko Nakamura

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0654 ,  A61K35/12 ,  C12N5/0655 ,  C12N5/0668 ,  C12N2501/17 ,  C12N2502/1394 ,  C12N2502/99

    摘要： Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and is positive for at least one surface marker from among Tie2 and GD2. That is, the intervertebral disk nucleus pulposus stem cell is characterized by being at least Tie2-positive for the surface marker and) possesses a self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. Also provided is an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.

    摘要翻译： 提供可用于治疗椎间盘疾病的椎间盘髓核干细胞或祖细胞。 椎间盘髓核细胞的特征在于从脊椎动物的椎间盘髓核中分离，并且对于Tie2和GD2中的至少一个表面标记是阳性的。 也就是说，椎间盘髓核干细胞的特征在于对于表面标志物至少为Tie2阳性，并且具有能够分化成脂肪细胞，骨细胞，软骨细胞和神经元的自我更新能力以及多能性。 还提供了一种椎间盘髓核祖细胞，其特征在于对于表面标记至少具有Tie2阴性和GD2阳性，并且能够分化成任何脂肪细胞，骨细胞，软骨细胞和神经元。

    Hydrophilic film and process for producing the same
    10.
    发明授权
    Hydrophilic film and process for producing the same 失效
    亲水膜及其制造方法

    公开(公告)号：US06214382B1

    公开(公告)日：2001-04-10

    申请号：US08836049

    申请日：1997-12-23

    申请人： Tamiyuki Eguchi ,  Kiyoshi Ando ,  Yasuo Shimizu

    发明人： Tamiyuki Eguchi ,  Kiyoshi Ando ,  Yasuo Shimizu

    IPC分类号： A61K914

    CPC分类号： B01D67/0088

    摘要： This invention provides a hydrophilic membrane wherein a hydrophilic cellulose derivative of a number average molecular weight of 2000˜8000 is adsorbed irreversibly to a hydrophobic membrane of an aromatic polymer. Since an amount of leaching substances is extremely small, the membrane can be used suitably in such fields as medical applications, electronics, etc. where even a quite small quantity of leaching substances from the membranes is limited especially small.

    摘要翻译： 本发明提供一种亲水性膜，其中数均分子量为2000〜8000的亲水性纤维素衍生物不可逆地吸附在芳香族聚合物的疏水性膜上。由于浸出物质的量极少，因此可以适当地使用 诸如医疗应用，电子等领域，甚至来自膜的相当少量的浸出物质被限制得特别小。