发明申请
- 专利标题： Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy
- 专利标题（中）： 鉴定表面相关抗原的肿瘤诊断和治疗
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申请号： US12851980申请日： 2010-08-06
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公开(公告)号： US20110014628A1公开(公告)日： 2011-01-20
- 发明人: Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
- 申请人： Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
- 申请人地址： DE Mainz
- 专利权人： GANYMED PHARMACEUTICALS, AG
- 当前专利权人： GANYMED PHARMACEUTICALS, AG
- 当前专利权人地址： DE Mainz
- 优先权： DE102004023187.7 20040511
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K14/00 ; C07H21/04 ; C07K16/00
摘要：
An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.
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